Health
Rare inflammatory syndromes in children with COVID-19 as described
SARS-CoV-2 (shown here in electron microscope image). Credit: National Institute of Allergy and Infectious Diseases, NIH
Researchers at the Karolinska Institute and Science for Life Laboratory in Sweden and the University of Tor Vergata in Rome, Italy, have found that the immune response of children affected by a rare but life-threatening inflammatory syndrome associated with COVID-19 Has been mapped. Research published in scientific journals cell, Showed that the inflammatory response was different from Kawasaki disease and severe acute COVID-19.
With the current SARS-CoV-2 pandemic, there are few exceptions, Children He showed mild symptoms. However, pediatricians have discovered a new life-threatening inflammatory syndrome similar to Kawasaki disease It has been termed a multisystem inflammatory syndrome in children associated with COVID-19, MIS-C (see box).
In a new collaboration, researchers have unraveled the immunological aspects of this rare condition. They compared Blood sample A sample of 28 Kawasaki disease patients from 13 MIS-C patients treated at the Karolinska University Hospital in Stockholm, Sweden and the Bambinojez Children’s Hospital in Rome, Italy, 2017-2018 before COVID-19. Collected in the year. The analysis also included samples from children with mild COVID-19.
Different from other inflammatory conditions
“Our results show that MIS-C has a completely different inflammatory state than Kawasaki disease, despite having some common features,” Pero Brodin said. I will. Investigation. “The hyperinflammation and cytokine storms detected in children with MIS-C are also different from those seen in adult patients with severe acute COVID-19, which was recently described in another publication.”
Comparing MIS-C with these other inflammatory conditions, this study observed different frequencies of specific immune cell populations, inflammatory cytokines in blood, and chemokines. Unlike children with Kawasaki disease and mild COVID-19, children with MIS-C lacked IgG antibodies to the common cold coronavirus. Researchers have also discovered several autoantibodies that target the body’s own proteins and may contribute to the pathogenesis of MIS-C. They are also currently investigating the genetic risk factors for developing MIS-C after SARS-CoV-2 infection.
Add pieces to the puzzle
“There is an urgent need to better understand why a few children with SARS-CoV-2 develop MIS-C, and we’re adding a piece to the puzzle,” Dr. Brodin said. I will. “We need better knowledge of the etiology to develop optimal treatments that can suppress cytokine storms and hopefully save lives, and vaccines to avoid MIS-C caused by vaccination. It is important.”
Immunology of multisystem inflammatory syndrome in children with Camilla Rosat Concirio et al. COVID-19, cell (2020). DOI: 10.1016 / j.cell.2020.09.016
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Karolinska Institute
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