Health
A new way to fight cancer with molecular fibers
The physical structure of a cancer cell is destroyed by the web formed inside the cell-activating self-destruction mechanisms. Credit: MPI-P
According to the German Federal Statistical Office, cancer is one of the most frequent causes of death, accounting for almost 25% of all deaths. Chemotherapy is often used as a treatment, but it has side effects on healthy organs. Scientists led by David Ng, Group Leader of the Max Planck Institute for Polymer Research, are trying a completely different approach. To locally destroy the structure of cancer cells in order to activate the self-destruction mechanism. Researchers have already demonstrated early success.
Cancer is cell It grows out of control and leads to tumor growth. In addition to Radiation therapy, Cancer is often treated with chemotherapy. Administered chemicals affect biochemical processes, especially cancer cell processes, ensuring that the tumor is unable to grow and dies slowly.
However, chemotherapy stresses the body and becomes ineffective over time. In addition to Side effects, Cancer adapts to chemicals, resists their effects, and may evolve new growth methods. “We are currently taking another approach, trying to prevent cancer by affecting biochemical processes, but trying to attack its structure directly,” Polymer Research.
Scientists have made a kind of molecular Lego bricks synthetically for this purpose, and these bricks migrate to both normal and cancer cells through special attachments. Although legoblock alone is harmless, the unique conditions present in cancer cells trigger a series of chemical reactions. “In cancer tissue, the environment is much more acidic than in normal tissue,” says Ng. “In addition, due to the increased metabolic activity of cancer, much more reactive oxidative molecules are found in cancer cells-and we take advantage of them.”
If both conditions are met, individual LEGO blocks can connect to form a large web-like network. This web, which grows inside the cancer cells, is very stable and transforms the cancer cells from inside to outside. Cancer cells that are unable to cope with physical stress activate the self-destruct mechanism. “In this way, we attack cancer cells in ways that we can’t defend against,” Ng says.
Researchers have so far been able to investigate the method of cancer cells in laboratory culture and prove that the cells die within a very short time of about 4 hours. In the future, their method will be cancer Treatment and further research are ongoing.
From a viewpoint, Ng, Weil and others will work on the biodegradation of the net after improving the accuracy of deformation. cancer cell Is dead They have their results Journal of the American Chemical Society..
Michaela Pieszka et al, Controlled supramolecular assembly in living cells by sequential multi-step chemical reactions, Journal of the American Chemical Society (2020). DOI: 10.1021 / jacs.0c05261
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