Use of NSAIDs during coronavirus infection does not aggravate symptoms, studies say

In the early stages Coronavirus Use of a pandemic Nonsteroidal anti-inflammatory drug (NSAID), such as Ibuprofen, Not recommended due to concerns that it could lead to more serious cases COVID-19 (New Coronavirus Infection) (# If there is no character limit, add parentheses when first appearing. However, New research NSAIDs such as ibuprofen and diclofenac, announced this week in PLOS Medicine, have been found to have no adverse effects on people infected with COVID-19. Anti-inflammatory drugs are commonly used to treat fever, pain, and pain.

“Overall, the risk of all outcomes studied was similar among users and nonusers of ibuprofen, and other NSAIDs,” the researchers said in a published report.

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A new study published this week in PLOS Medicine found that NSAIDs such as ibuprofen and diclofenac do not adversely affect people infected with COVID-19. Anti-inflammatory drugs are commonly used to treat fever, pain, and pain.

Researchers at the University of Southern Denmark, Aarhus University Hospital, and the Danish Pharmacy have collected data on more than 9,000 Danish residents positive for the new coronavirus from 27 February to 29 April. I looked up the registry data on usage. Studies show NSAIDs, hospitalizations, ICU admissions, mechanical ventilation, 30-day mortality, and rates of acute renal replacement therapy. According to the study, of the 9,326 people studied, 248 received prescriptions for NSAIDs within 30 days of positive COVID-19 testing.

The researchers concluded that there was no association between the use of NSAIDs and the outcome of new coronavirus infections.

“We [the] The use of NSAIDs was associated with 30-day mortality and adverse outcomes in a national population of SARS-CoV-2 positive individuals. NSAID use was not associated with a 30-day increase in mortality. This was solid with a series of complementary analyses,” the study author said in a published report.

“Likewise, [the] The use of NSAIDs was not associated with increased risk of hospitalization, ICU hospitalization, mechanical ventilation, or renal replacement therapy in a coordinated analysis,” the team of researchers also said in the study.

In a matched cohort, we found that 6.3% of COVID-19-positive individuals who used NSAIDs died 6.3% compared to 6.1% who did not use anti-inflammatory drugs.

In a group of patients infected with COVID-19 using NSAIDs, researchers found that 24.5% were hospitalized and 4.9% were hospitalized in ICU. On the other hand, of the SARS-CoV-2 positive patients who did not take NSAID, 21.2% were hospitalized and 4.7% were hospitalized in ICU.

“There is no reason to discontinue the well-documented use of NSAIDs during the SARS-CoV-2 pandemic, given the available evidence,” the study authors said.

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“However, the established side effects of NSAIDs, especially the renal, gastrointestinal, and cardiovascular effects, should always be considered, and NSAIDs should be used for all patients in the shortest possible time, at the lowest possible dose. Should be used in.”

Currently, the US Food and Drug Administration (FDA) website“At this time, the FDA is unaware of the scientific evidence linking the use of NSAIDs such as ibuprofen to the exacerbation of COVID-19 symptoms. Authorities are investigating the issue further and more information is available.” Communicate publicly when possible. However, all prescription NSAID labels say, “The pharmacological activity of NSAIDs in reducing inflammation and, in some cases, fever reduces the usefulness of diagnostic indications in detecting infections. May occur.” “

The FDA also recommends discussing the use of NSAIDs with your doctor.

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