Health
Animal studies have proven the efficacy of covaxin, an Indian Covid-19 vaccine candidate, says Bharat Biotech-Indian News
The drug company has successfully tested covaxin, a Covid-19 vaccine candidate from Bharat Biotech International Limited, in a “significant immunogenicity and protection” of shots in a phase I clinical trial in India. It states that it showed “effect”.
Developed by the Indian Medical Research Council (ICMR) and Bharat Biotech, Covaxin Tested at 12 laboratories across India.. The Hyderabad-based company said data from studies on primates demonstrate the immunogenicity of vaccine candidates.
“Bharat Biotech proudly presents the results of COVAXIN’s animal studies-these results demonstrate protective effects in a live virus challenge model,” Bharat Biotech tweeted Friday.
In its release, Bharat Biotech states that it has developed and evaluated the protective efficacy and immunogenicity of the inactivated Sar-CoV-2 vaccine (BBV152) or covacin in rhesus monkeys. The 20 macaques were divided into four groups of five each, he said.
Read again | Want to enroll in a vaccine test? Know eligibility
“One group received placebo, but three groups were immunized with three different vaccine candidates on days 0 and 14. All monkeys received SARS-CoV- 14 days after the second dose. Attacked in 2. Defensive response was observed with increased SARS-CoV-2 specific IgG and neutralizing antibody titer 3 weeks after immunization.
“In the vaccination group, viral clearance was observed from bronchoalveolar lavage fluid, nasal swabs, pharyngeal swabs, and lung tissue 7 days after infection,” he added.
“Unlike the placebo group, which showed the characteristics of interstitial pneumonia and the localization of viral antigens by immunohistochemistry of alveolar epithelium and macrophages, histopathological examination of the vaccinated group showed no evidence of pneumonia. “He added.
In summary, vaccine candidates have been found to provoke a strong immune response. Therefore, prevention of primate infections and illness due to high-dose exposure to live SARS-CoV-2 virus. “
Bharat Biotech Approved A Phase II study will be conducted by the Central Drugs Standard Control Organization earlier this month. In June, it announced that it had successfully developed Covaxin in collaboration with ICMR and the National Institute of Virology (NIV).
The SARS-CoV-2 strain was isolated at NIV, Pune and transferred to Bharat Biotech. Indigenous inactivated vaccine candidates are being developed and manufactured at Bharat Biotech’s high containment facility in the Genome Valley of Hyderabad.
Kovacin One of the leading candidates for the race Covid-19 vaccine in India. This is an “inactivated” vaccine. It works by injecting the killed virus so that the body builds antibodies without threatening the virus.
Each stage of a vaccine’s clinical trial tests its safety and ability to generate an effective immune response. Phase 1 focuses on safety and dosage determination in a small group of healthy participants, while Phase 2 examines the efficacy of the vaccine. Phase 3 examines these aspects of a much larger population that represents a wide range of demographics.
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