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The Indian coronavirus genome has similarities to the 5.39 pc mutation in 72 countries: Tribune India

 


New Delhi, September 13

The Indian coronavirus genome has 5.39% mutational similarity with 72 countries. Research has been found by a group of researchers seeking to identify viral and human genetic diversity and potential molecular targets to find the best answer to combat COVID-19.

Mutations in the genetic material of an organism are a natural “error” in the process of cell replication and can give the virus a new “power” of survival, infectivity, and pathogenicity. Vaccines and drugs can affect the ability of a vaccine or drug to bind to the virus or provoke a specific immune response against the virus.

The study also found that the United States, United Kingdom, and India were the top three countries with geometric mean of mutation similarity scores of 3.27%, 3.59%, and 5.39%, respectively, with the other 72 countries. ..

Indrajit Saha, an assistant professor in computer science and engineering at the Calcutta National Institute for Technical Teacher Training, and his team have also developed a web-based COVID-Predictor for predicting virus sequences online. Of machine learning.

Scientists use single-base polymorphisms to identify the number of viral strains, identify potential target proteins of the virus and human host based on protein-protein interactions, and are highly immunogenic. Recognizing Synthetic Vaccine Candidates Based on Conserved Genomic Regions Detects viral miRNAs that are antigenic and are also involved in the regulation of human mRNAs.

They individually analyzed 566 Indian SARS-CoV-2 genomes and found genetic diversity in terms of point mutations and single nucleotide polymorphisms.

Scientists primarily found that 57 of the 64 SNPs were present in 6 coding regions of the Indian SARS-CoV-2 genome, not all synonyms. This work has already been published in the Infection, Genetics, and Evolution journals.

They extended this study to more than 10,000 sequences worldwide and found 20,260, 18,997, and 3514 unique mutations throughout the world, including India, including India, including India. — PTI

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