Health
Gestational diabetes may accelerate the biological age of children
Researchers say that children born to mothers who have diabetes during pregnancy may age biologically faster and be at increased risk of obesity and high blood pressure.
This study, published in the journal Epigenetics, investigated how more than 1,000 children born to mothers in China were aging at the cellular level.
According to the Cleveland Clinic Abu Dhabi, gestational diabetes is a condition characterized by high blood sugar (sugar) levels found during pregnancy and is diagnosed in 20.4% of pregnant women in the UAE.
Researchers investigated exposure to intrauterine gestational diabetes and DNA methylation, or epigenetic age. This shows how experience and exposure reflect the true biological age of early childhood.
Accelerated aging, which can be determined by assessing whether a person’s estimated DNA methylation age is greater than chronological, has been shown to be associated with cardiovascular risk and poor health in later years.
Researchers measured the epigenetic age of 1,156 children between the ages of 3 and 10 in Tianjin, China, and examined the difference from age.
They say that children born to mothers who suffered from diabetes during pregnancy are older or “older” than their actual age, and this epigenetic age is higher weight, body mass. We found that it was related to index, body fat percentage, upper arm, surroundings and blood pressure.
“These findings suggest that gestational diabetes can have long-term effects on the epigenetic aging of offspring and worsen cardiometabolic health.”
The findings support the need for further studies using longitudinal samples to assess the association between epigenetic age and the subsequent development of metabolic disease in adults.
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