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Paper microneedle patch designed for self-monitoring of blood glucose levels

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I have heard about it Microneedle patch I’ve heard about cheap and disposable items before Paper biomedical test kit.. Japanese scientists are now combining the two with a paper-lined microneedle patch that measures blood glucose.

Microneedle patches usually consist of small polymer squares, underneath which are studded with a series of small needles.

When such a patch is pressed against the body, the needle pierces the top layer of the skin painlessly. These needles draw in the interstitial fluid that surrounds the skin cells and allow them to be analyzed. Since the biomarker level of the fluid usually corresponds to the level of blood flow, microneedle patches can often be used. instead Of a more painful subcutaneous needle than taking an actual blood sample.

For the new experimental device, the University of Tokyo team began by pouring a mixture of molten biodegradable polymer and salt into a mold incorporating a small conical cavity. These formed the microneedles. The mold was then turned inside out with the needle side up and the flat back of the polymer layer pressed against a sheet of paper. This caused the polymer to flow into the pores of the paper and bond with it.

After removing the polymer / paper combo from the mold, the microneedles were cooled in a salted solution. This left the needle filled with thousands of small pores that attracted fluid through capillarity. Finally, I used double-sided tape to attach the glucose-sensitive paper to the base paper.

When the resulting patch was tested on an agarose gel containing dissolved glucose, the needle pores were successfully drawn into the liquid and passed through the base paper to reach the glucose sensing paper. This caused the latter to change color, indicating the amount of glucose present in the gel.

After the further development of microneedle patches, customers are expected to be able to test prediabetes using inexpensive, disposable, biodegradable and biocompatible devices at home. However, it is said that by implementing paper that is sensitive to biomarkers other than glucose, this technology can be adapted to testing in a variety of other conditions.

The study is described in a recently published paper in the journal Medical devices and sensors..

Source: University of Tokyo

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