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Studies argue that prescribed immunosuppressants may not increase the risk of COVID-19 infection



Immunosuppressants are given to patients who have had an organ transplant or have an autoimmune disease.

Studies argue that prescribed immunosuppressants may not increase the risk of COVID-19 infection

New visualization of COVID-19 virus. Image courtesy of Fusion Medical Animation

A group of researchers at the American healthcare company Henry Ford Health System found that people using immunosuppressive drugs for common skin and rheumatoid arthritis and psoriasis are not at increased risk of developing COVID-19. Therefore, he insists that he should continue to take the medicine. ..

Published in Journal of the American Dermatology Society Concludes that there is no evidence that the use of a single immunosuppressant may put you at risk for severe COVID-19. In fact, if you get sick, it may help reduce your chances of hospitalization.

Every time news release According to the healthcare company, Henry Ford dermatologists treat a vast population of patients with skin inflammatory diseases in Michigan, including those with psoriasis, urticaria and eczema. The use of immunosuppressants in the treatment of these diseases has prompted researchers to conduct this trial.

the study

In this study, researchers conducted a retrospective cohort analysis of patients who were positive for COVID-19 between February 1 and April 18, 2020 in the Henry Ford Healthcare System.

Approximately 213 patients with immune-mediated inflammatory disease (IMID) were included in the study. Of these, about 36.2% were COVID-19 positive. Scientists noted in this study:

  • 36.2% of patients who tested positive for COVID-19 showed no risk of hospitalization or the need for ventilation.
  • Those who were taking the prescribed TNF alpha inhibitor were less likely to be hospitalized. TNFα inhibitors are immunosuppressive drugs used to control inflammation.
  • Patients receiving monotherapy were not at increased risk of receiving COVID-19 or becoming seriously ill. However, those receiving multidrug therapy were at increased risk of hospitalization.

Previous evidence

People taking immunosuppressive drugs were intuitively included in the high-risk category of COVID-19, along with those with weak immunity, the elderly, and people with chronic illness. However, due to lack of clinical evidence, scientists are skeptical of this recommendation.

Immunosuppressants are given to patients who have had an organ transplant or have an autoimmune disease. Patients taking these medications are usually prone to infections, especially upper respiratory tract infections such as the common cold and cough. However, previous case studies and studies conducted in a small number of people who received immunosuppressive drugs pointed out that the course of COVID-19 in these patients was otherwise different from that of healthy patients. not.

In fact, studies show that immunosuppressants were not a problem with the development of SARS and MERS (the outbreak of two related coronaviruses in the 21st century). As a result, many organizations, including the American Society of Gastroenterology, the British Society of Gastroenterology, the British Society of Rheumatology, and the American Academy of Dermatology, have been prescribed immunosuppressants (prescribed) to patients while taking appropriate precautions against COVID-. If you have), we suggest that you continue to use it. 19.

In a news release, study lead author and Henry Ford dermatologist Veenstra said, “If an immunosuppressive drug is needed to properly control the condition, continue it during the pandemic. You shouldn’t be afraid. ” “Physicians prescribing these drugs should feel comfortable whether to continue or resume taking these drugs … they support the safety profile of these drugs during the COVID-19 pandemic. You can advise the patient that you have the data. “

For more information, see the following articles. What does immunodeficiency mean?..

Firstpost’s Health Article is produced by, India’s first and largest resource for validated medical information. At myUpchar, researchers and journalists work with doctors to provide all the information about health.

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