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Small study supports donor plasma therapy for severe COVID-19



Ej Mundell, Healthday Reporter

Small study supports donor plasma therapy for severe COVID-19

(HealthDay)-There was some controversy in treating patients with severe coronavirus throat with donated plasma from COVID-19 survivors. But a small new study suggests that it may have real benefits.

In a study of 39 patients with severe COVID-19 treated at a hospital in New York City, the researchers said the treatment appeared to improve survival.

Plasma is a component of blood that contains immune system antibodies. So-called”“COVID-19 survivors are rich in antibodies to SARS-CoV-2 and it is believed that injecting plasma into COVID-19 patients may help them fight their disease. ..

On August 23, the U.S. Food and Drug Administration made an unusual and controversial move to give urgent approval for the use of COVID-19 convalescent plasma — despite the lack of evidence of efficacy by randomization. ..

While those trials are underway, anecdotal evidence in the meantime suggests at least that the treatment is safe, one expert said.

Dr. Liise-anne Pirofski, Head of Biomedical Research at Albert Einstein Medical College and Montefiore Medical Center in New York City, said:

But does convalescent treatment really help speed recovery from severe COVID-19?

To aid in the discovery, a team led by Dr. Nicole Bouvier of Mount Sinai Hospital in New York City tracked the outcomes of 39 patients admitted with COVID-19. They were all very ill: by the time these patients were given the donor’s plasma transfusion, 87% needed supplemental oxygen to breathe, and 10% were in the ventilator. ..

The results of 39 transfused patients were compared with those of 156 other COVID-19 patients with similar symptoms and medical history who had not received experimental treatment.

Report on September 15th in the journal Natural medicine, Bouvier’s group concluded that “restorative plasma is potentially effective against COVID-19.”

By day 14 after receiving plasma therapy, researchers found 28% of patients who did not receive fluids in the “control” group, compared to 18% of patients who still needed oxygen supplementation. It was.

By the end of the May study, 13% of those who got convalescent plasma died compared to 24% of those who did not, the study authors said.

Still, the findings are not conclusive, as this study was not a large, randomized clinical trial. “Additional research is needed to confirm these findings and draw more definitive conclusions about convalescent efficacy. Blood transfusions for the treatment of COVID-19 in different populations, “the team concluded.

Pilovsky agreed. “I think everyone agrees that the knowledge gaps that exist can best be addressed by high-quality testing,” she said.

Follow the latest news about the outbreak of coronavirus (COVID-19)

For more information:
The American Society of Hematology Convalescent Plasma and COVID-19..

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Quote: For small studies, severe COVID-19 (2020) obtained from on September 15, 2020. Supports donor plasma therapy (September 15, 2014).

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