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University of Pittsburgh scientists discover antibodies that “neutralize” coronavirus

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Researchers at the University of Pittsburgh School of Medicine said that the antibody component that “completely and specifically neutralizes the SARS-CoV-2 virus” could be isolated and used as a viable therapeutic and prophylactic agent against the coronavirus. I am.


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The antibody component, which is one tenth of the full size antibody, is used to make the drug Ab8. Researchers reported in a journal cell on Monday that the drug was very effective in preventing and treating coronavirus in mice and hamsters. Scientists say the drug doesn’t even bind to human cells, suggesting that it doesn’t have a negative effect on humans.

Due to the small size of the component, it can be developed as an inhaled mist or injectable instead of IV.

“Ab8 can be used not only as a treatment for COVID-19, but also to prevent people from getting SARS-CoV-2 infection,” said the University of Pittsburgh Medical Center and Pittsburgh. statement..

“Large size antibodies are effective against other infections and are well tolerated. Effective treatments to protect patients with COVID-19 and those who have never been infected and have no immunity. I’m hoping to be, “he said.


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The drug was studied in collaboration with researchers at the University of North Carolina at Chapel Hill (UNC), the University of Texas School of Medicine (UTMB) at Galveston, the University of British Columbia, and the University of Sascachuwan.

Researchers at UTMB’s Center for Biodefense and Emerging Diseases and the Galveston National Laboratory have tested the drug and found that it blocked the virus from entering cells.

“The COVID-19 pandemic is a global challenge facing humanity, but biomedicine and human ingenuity are likely to overcome it,” Mellors said. “I hope the antibodies we discover will contribute to that victory.”


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