Australian conifers reveal a whole new family of neurotoxins

A new study at the University of Queensland unravels the mystery of why one of the most poisonous plants on the planet was stabbed. The previously unknown discovery of neurotoxins explains how Australian stinging trees cause extraordinarily long-lasting intolerable pain.

Australia is famous for its wide selection of poisonous animals. From spiders and snakes to scorpions and jellyfish, the country is very famous for its dangerous wildlife.Everything in Australia wants to kill you“It’s an interesting meme.

Well, not only animals take you out, but plants are also dangerous. Dendrocnide moroidesIs commonly known as the Zimpy-Zimpy stinging tree and is one of the most poisonous plants in the world. Plant toxins are unlikely to kill you, but there are many stories that explain the horrific pain that their stings cause.

The pain is Written by many As the worst kind of pain you can imagine. One researcher suggested that he was stabbed with “a feeling of being burned by hot acid and at the same time electrocuted.”

Institute for Molecular Bioscience, University of Queensland

“Like other coniferous plants such as nettles, giant conifers are covered with needle-like appendages called trichomes, which are about 5 millimeters in length. The trichomes look like fine hair. However, in actual contact it acts like a subcutaneous needle that injects toxins in the skin, “explains a new study, the corresponding author of Irina Vetter.

Well, not only animals take you out, but plants are also dangerous.

The pain caused by this plant has been a mystery to researchers. Experiments with small molecules known to be present in plants have failed to reproduce the intense, unusually long-lasting pain caused by stings. It was clear that undiscovered neurotoxins must play a major role.

Institute for Molecular Bioscience, University of Queensland

A new study by a team of researchers at the University of Queensland describes the discovery of a previously unknown pain-inducing peptide responsible for the unique neurotoxic effects of plants. A new class of miniproteins is called ginpytide, which derives from the unique name of the plant, ginpy.

“Although they are of plant origin, zippies are similar to spider and corn snail toxins in that they fold into a 3D molecular structure and target the same pain receptors. This is undoubtedly zippy. The zippy tree really becomes a “poisonous” plant. “Vetter explains.

The study considered the mechanism of action and found that these gympitides appear to cause permanent changes in the sodium channels of sensory neurons. This action is believed to explain why plant-stabbed people can experience repeated pain sensations over months, Or a few years, After the first sting.

“By understanding how this toxin works, we want to provide better treatment to people who have been bitten by plants and to relieve or eliminate pain,” Better adds. relief. “

New research published in journal Scientific progress..

Source: University of Queensland

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