Researchers have found that more than half of pregnant women hospitalized with COVID-19 are asymptomatic.
Miranda de la Hoi had about 55% of 598 hospitalized pregnant women with COVID-19 asymptomatic, whereas 16% of symptomatic pregnant women were admitted to the intensive care unit (ICU). About 9% needed a ventilator and two were reported dead. CDC PhD and his colleagues Weekly morbidity and mortality report (MMWR)..
Of the 458 women who finished their pregnancy at discharge, 448 gave birth, a loss of 10 pregnancies that occurred in both asymptomatic and symptomatic women. However, there were no ICU hospitalizations, mechanical ventilations, or deaths among asymptomatic women, the authors said.
“Tests based on the presence of symptoms may miss COVID-19 infection during pregnancy,” the researchers wrote. “Surveillance of COVID-19 in pregnant women, including asymptomatic infections, is important for understanding the short-term and long-term effects of COVID-19 on mothers and newborns.”
The current CDC test policy is that if the patient is in close contact with a patient with COVID-19 but is asymptomatic. Patients “do not necessarily need testing” Unless they are “vulnerable individuals” or at the discretion of the healthcare provider or state / local public health authorities.
“Pregnant women make up a significant portion of COVID-19-related hospitalizations among women of reproductive age,” Delahoy and co-authors added.
They surveyed data from COVID-NET, a population-based monitoring system for COVID-19 infections identified in the laboratory, in 14 states, 13 of which provided the data for this report.
Of the 7,895 women aged 15-49 years hospitalized for COVID-19, 598 were pregnant. They had a median age of 29 years, and of the 577 people who reported race / ethnicity, about 43% were Hispanic and about 27% were non-Hispanic blacks. Approximately 21% of pregnant women hospitalized with COVID-19 had at least one underlying disorder, including 8% of asthma and 4% of hypertension. Most women were hospitalized in late pregnancy.
Reasons for hospitalization were available to 324 women, three-quarters of whom were hospitalized for obstetric indications, including delivery and childbirth. About 20% were hospitalized for COVID-19-related illness. This was the most common reason for hospitalization in the first and second trimesters, but obstetric indications were the most common reason for the third trimester.
Of the 445 births, 87.4% were term births and 13% were preterm births. Researchers pointed out that this is higher than the 10% rate of preterm birth in the general population in 2018. Of the pregnancies that led to childbirth, preterm birth was reported in 23% of symptomatic pregnant women and 8% of asymptomatic pregnant women.
Two babies have died. Both were born to symptomatic mothers who required invasive mechanical ventilation.
Faster preterm birth rate, stillbirth
Ah Second report In MMWR, According to CDC’s Lakshmi Panagiotakopoulos, MD, and colleagues, not only is the asymptomatic infection rate higher, but the prevalence and stillbirth of preterm birth is also higher than the baseline rate of pregnant women hospitalized with COVID-19. It has become.
From March 1st to May 30th, researchers examined data from the Vaccine Safety Datalink (VSD) monitoring system at eight healthcare centers in the United States and examined 105 in-hospital SARS-CoV- 2 I found an infected pregnant woman. The median age of all women was 30, with 62% being Hispanic or Latin.
Of the 62 women hospitalized for obstetric reasons, 50 (81%) are asymptomatic, similar to the proportion seen in New York City at the beginning of the pandemic.
Of the 93 women who gave birth, 15% were premature and 3% were stillborn. Researchers found that the prevalence of preterm birth was “close to 70% of the baseline rate of VSD during the study” (9% of live and stillbirth) and the prevalence of stillbirth was “SARS-CoV-during the study.” From the VSD baseline rate (0.6%) of 2 “.
In particular, of the 43 women admitted with COVID-19, 30% required admission to the ICU and 14% required mechanical ventilation. One woman died of COVID-19.
Not surprisingly, many pregnant women hospitalized with COVID-19 were pre-pregnant obese and asymptomatic pregnant women hospitalized for obstetric reasons (44% vs. 30%, respectively). Similar results were seen for the prevalence of gestational diabetes in those admitted with COVID-19 and those admitted for obstetric reasons (26% vs. 8%).
Delahoy did not reveal a conflict of interest. The co-authors reported their relationship with MedImmune, Regeneron, PaxVax, Pfizer, GSK, Merck, Novavax, Sanofi-Pasteur, Micron, Janssen, AbbVie, Kentucky BioProcessing, and VBI vaccines.
Panagiotakopoulos does not disclose any conflicts of interest. Co-authors have disclosed support from Amgen, Merck & Co, Radius Health, ON Diagnostics, Pfizer, Sanofi Pasteur, GlaxoSmithKline, and Protein Science.
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