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Smoking associated with cerebral bleeding in a large long-term study of twins




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A study of the Finnish Twin Cohort reaffirmed the association between smoking and subarachnoid hemorrhage (SAH). This is a type of hemorrhagic stroke that occurs under the membrane that covers the brain and is often fatal. A new study by Finnish researchers announced today stroke..

A 2010 study of nearly 80,000 twins in Denmark, Finland and Sweden suggested that SAH was highly associated with external risk factors and had little to do with genetic effects. Twins share all or half of their genes (same vs siblings) and are of value to studies designed to assess the role of genetics. Onset of illness.

In this study, researchers sought to clarify the factors involved when only one of the twins was suffering from fatal bleeding. He assumed that smoking, the most important environmental risk factor, could play an important role. This study is a Finnish twin cohort, Born before 1958, lived in 1974, 32 of 32,564 people (homosexual, twin pairs in Finland) lasted more than 42 years between 1976 and 2018. A fatal cerebral hemorrhage was seen in smokers.

“Our study provides further evidence of the link between smoking and intracerebral hemorrhage,” said corresponding researcher BM, Ilari Rautalin, who holds a six-year medical and doctoral degree. A student at the University of Helsinki, Finland.

The data collected from the survey included smoking. Hypertension (diagnosis or use of antihypertensive drugs); physical activity; body mass index; education; and alcohol use. Participants were divided into two groups: smokers (occasionally or now) or nonsmokers (previously and previously). Current smokers are categorized according to the number of cigarettes smoked per day. Medium, 10-19 heavy, 20 or more.

Analysis of 120 fatal bleeding events found:

  • Four deaths occurred between the two pairs of twins. Of the remaining 116 deaths, one twin died of cerebral hemorrhage and the other died of another cause and moved during follow-up or was still alive at the end of the study follow-up. Was.
  • Heavy and moderate smokers had a three-fold risk of fatal bleeding in the brain, while light smokers had a slightly lower risk of 2.8-fold.
  • The median age at the time of fatal cerebral hemorrhage was 61.4 years.

Risk factors like , Lower Rate and being female, unlike previous studies, were not found to have significant impacts in this study. Smoking was consistently associated with fatal hemorrhage in the brain in both men and women and stroke deaths within twin pairs in which only one twin died of SAH.

There are no data on non-fatal SAH events in the current study, and researchers were unable to estimate the effect of previous smoking on these cerebral hemorrhage. Never with a former smoker Integrated into the smoking cessation category. Researchers were also unable to confirm the origin of the SAH aneurysm (patient data were not available) and may contain several SAH events other than the aneurysm.

“A long-term study of these twins Dr. Rosemary Robertson, MD, a vice-science and medical director of the American Heart Association who was not involved in the study and co-director of the AHA Center for Regulatory Science, said. If you have already started, quitting is an integral part of primary prevention. ”

Female smokers face the greatest risk of cerebral hemorrhage

For more information:
Smoking causes subarachnoid hemorrhage, if not fatal stroke (2020). DOI: 10.1161 / STROKEAHA.120.031231

Quote: Smoking associated with intracerebral hemorrhage in a large long-term study of twins (September 17, 2020), September 17, 2020, https: // -large-long- term-twins.html

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