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Gender, Birth Hormones May Determine Risk of Immune-Related Diseases

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Mast cells, also known as mast cells or mast cells, are a type of white blood cell that plays an important role in the immune and neuroimmune systems.

Gender, Birth Hormones May Determine Risk of Immune-Related Diseases

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Men and women are biologically different, so it is quite natural to assume that the disease has different effects on them. Studies show that these differences appear in any illness. COVID-19, heart disease, stroke or Autoimmune disease.. Most studies have shown that it is the way adult sex hormones work and signal the female immune response that determines these points of difference.

New research published in Minutes of the National Academy of Sciences Perinatal hormones (hormones produced in the body immediately before or after birth), especially when associated with mast cells, suggest that they can cause life-threatening illness.

Mast cell-related diseases and sexual bias

Mast cells, also known as mast cells or mast cells, are a type of white blood cell that plays an important role in the immune and neuroimmune systems. They are essential in creating the first line of defense against infectious diseases or other illnesses. Studies have shown that these mast cells show sexual bias, and neuroinflammatory pain disorders such as allergies, anaphylaxis, asthma and migraine, and autoimmune diseases such as irritable bowel syndrome and ulcer are associated with mast cell dysfunction. Explain that you are.

Researchers explain that, unlike adult gonadal hormones and related disorders, mast cell-related health problems are beginning to appear in prepubertal children, especially girls. Using data collected from rodent models, they found that men had significantly less mast cell-mediated anaphylactic responses before puberty than women, a trend that persisted into adulthood. discovered. This reduced severity of mast cell-mediated anaphylaxis in men is associated with naturally high levels of androgens at birth, a group of hormones that play a role in male traits and reproductive function.

Why perinatal exposure to androgens is needed

This perinatal exposure to androgen is necessary to guide mast cell progenitor cells in the bone marrow and reduce the levels of mast cell mediators such as histamine, serotonin, and proteases. More of these inflammatory cell mediators are accumulated in female mast cells, which are released into the system and provoke an aggressive immune response. This protects women from infections such as COVID-19, but increases the risk of inflammatory and autoimmune diseases.

Researchers also found that these androgen deficiencies in perinatal women could be ameliorated by increasing exposure to the androgen hormone testosterone propionate while it was still in the womb. .. They found that such intrauterine exposure reduced histamine levels in women and reduced the severity of anaphylactic reactions in adults. Therefore, this exposure may cause female mast cells to behave like male mast cells, reducing the risk of mast cell-related disease.

Here, this study was conducted in mice and future treatment of cell mediation to reduce gender-induced immune and other disorders requires further research, clinical trials, and worldwide approval. Please note that However, the results of this study are still encouraging, as they shed a very necessary light on why women are at such a high risk of contracting a particular disease.

For more information, see the following articles. Women’s health..

Firstpost’s Health Article is produced by myUpchar.com, India’s first and largest resource for validated medical information. At myUpchar, researchers and journalists work with doctors to provide all the information about health.

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