Health
Scientists identify new potential drugs for the treatment of COVID-19
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(IANS)
Scientists have identified new drugs that can prevent or mitigate the consequences of infection with SARS-CoV-2, the virus that causes COVID-19.
Preliminary results from studies conducted in animal models show that the drug 4-phenylbutyric acid (4-PBA) completely suppresses death caused by respiratory failure due to cellular stress, published in the Cytokines and Growth Factors Review. Shown the published research.
The inflammatory process identified in severe cases of coronavirus causes an uncontrolled release of excess cytokines. It is a molecule that organizes the body’s defenses and can even cause vascular hyperpermeability and multiple organ failure.
It is exactly what these researchers have proposed to control them, that is, to control such cytokines “storms” through infected cells.
“When cells are stressed by infection, they are called cytokines, and the more stress they have, the more persistent they become, causing this chaotic inflammation. Therefore, one possible treatment for COVID-19 is cell stress. Is to reduce stress, “said Ivan Duran, a principal investigator at the University of Malaga, Spain.
According to researchers, diversion of 4-PBA anti-stress drugs can regulate such cellular stress, which is also present in medical conditions such as diabetes, aging, or carcinogenesis, as a risk factor for COVID-19. It is classified.
The drug is already approved for clinical use in other diseases and is easy to apply clinically.
The study also identified the endoplasmic reticulum resident protein “BiP” (binding immunoglobulin protein) (stress blood marker) as an indicator of cellular stress status that is likely to be investigated and measured in affected patients.
Thus, BiP levels serve as an initial indicator of the COVID-19 risk group, apart from determining the efficacy of 4-PBA treatment, and establish a correlation between high levels after viral infection and inflammatory severity. I pointed out.
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