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Sleep time associated with cognitive decline in the elderly


There is a believable link between sleep The trajectory of time and cognitive decline has not been extensively studied in the past.

A team led by Peking University Hospital I, Peking University Clinical Institute, Yang Junma, and BA investigated the relationship between sleep time and cognitive decline. Senile Individuals from a pooled analysis of a pair of nationally representative aging cohorts in China and the United Kingdom.

In the cohort, investigators have data from Wave 4-8 (2008-2009-2016-2017) of the Longitudinal Study of English Aging and Wave 1-3 (2011-2015) of the Longitudinal Study of Health and Retirement in China. Used base settings.

The two randomly enrolled cohorts had a total of 28,756 participants, each living in the United Kingdom at least 50 years old or in China at least 45 years old.

Each participant self-reported their sleep time per night in a face-to-face interview.

Investigators sought key results for global cognitive z-scores calculated according to immediate and delayed recall tests, animal fluency tests, continuous sevens tests, intersecting pentagonal copy tests, and date orientation tests.

The team analyzed a total of 20,065 patients, 9254 UK aging longitudinal studies with an average age of 64.6 years, and 10,811 Chinese health and retirement longitudinal studies with an average age of 57.8 years.

A longitudinal study of aging in the UK had an interim follow-up of 8 years, and a longitudinal study of health and retirement in China had an average follow-up of 4 years.

Global cognitive z-scores for individuals less than 4 hours during 100,000 man-year follow-up (pooled β = -0.022; 95% CI, -0.035 to -0.009 SD / year; P= 0.001) and 10 hours or more (pooled β = -0.033; 95% CI, -0.054 to -0.011 SD / year; P= 0.03) fell faster than the 7 hour reference group per night after adjusting for many covariates.

Researchers also observed an inverted U-shaped association between sleep time and overall cognitive decline.

“This pooled cohort study found an inverted U-shaped association between sleep time and overall cognitive decline. It was cognitively inadequate (less than 4 hours per night) or excessive. It indicates that individuals (10 hours or more per night) need to be monitored. Sleep time, the authors wrote, “To investigate the mechanism of association between sleep time and cohort cohort, future Research is needed. “

Previously, researchers reported a strong association between sleep and cognitive function in the elderly, and many cohort studies examined whether baseline sleep duration was associated with cognitive decline and accidental dementia. Was inconsistent.

the study, “Relationship between sleep time and cognitive declineWas published online JAMA Network Open..


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