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The high risk of death for cancer patients with COVID-19 may be due to aging and an increase in existing symptoms

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A new study presented at this week’s ESC MID conference on coronavirus disease (ECCVID, online September 23-25) found that poor outcomes and high mortality in cancer patients with COVID-19 are generally more fundamental in older age. This study was done by Dr. Maria Rüthrich and her colleagues at the University of Jena Hospital in Germany, not because of the cancer itself, which suggests that the condition may be the cause.

In their study, the authors used data from the LEOSS (Lean European Open Survey of Patients with SARS-CoV-2) Registry. The German Society for Infectious Diseases (DGI) uses this registry to provide scientists and physicians with reliable clinical data to answer many urgent questions, such as when COVID-19 patients develop. created — What is the best possible treatment? Or how have you been successful to date? Under the new initiative, all the data collected will be Used in community-based analysis.

The authors retrospectively analyzed a cohort of 435 patients. Outcomes of COVID-19 (in COVID-19 cancer patients) from 3071 patients enrolled between March and August 2020.

The clinical manifestations of COVID-19 were described in four phases: uncomplicated (asymptomatic / mild symptoms), complex (needs oxygenation), critical (needs life support), recovery (improvement /) Discharge).

The median duration of observation was 14 days and the median length of hospital stay was 15 days. The most common age category was 76-85 (36.5%), with 176 (41%) women being women. The average CCI is 4.65, and the ECOG of 44/187 (23.5%) patients is above 2, indicating cancer patients who have limited self-care and can stay in bed or chair for more than 50% of the day. Solid tumors were found in 59% of patients, and lymphoma and leukemia were found in 18% and 11%, respectively.

A total of 193 patients (54%) had malignant malignancies and 96 (22%) had received anti-cancer treatment within the last 3 months before testing for SARS-CoV-2. At the time of detection of SARS-CoV-2, 272 (63%) pts were in the uncomplicated stage of COVID-19 disease. Progression of COVID-19 to complex / critical stages was seen in 206 (55%) patients, while 119 (28%) patients received emergency treatment. A total of 78 (66%) of these 119 patients required mechanical ventilation. The mortality rate for COVID-19 was 23%, but the mortality rate for men was twice that for women (28% vs. 14%). In addition, active cancer disorders (eg, recurrent or metastatic cancer, patients receiving anticancer therapy) had a higher mortality rate from COVID-19 than patients without active cancer disease (27%). vs 17%)

Compared to non-cancer patients, the distribution of age and comorbidities is significantly different. Therefore, cancer-free patients were younger (most frequent categories 56-65) and had fewer comorbidities (CCI 1.12 vs. 1.59). Survival at 30 days was worse in cancer patients (70%) and cancer-free patients (77%), with higher mortality rates (23% vs. 14%). However, after adjusting for age, gender, and comorbidities, COVID-19-induced survival and mortality were similar to those of non-cancer patients.

Dr. Rütrich concludes: And generally die because it is older than non With COVID-19, it has more fundamental conditions. It seems that it is not the cancer itself that causes these bad outcomes. ”


Research sheds light on cancer treatment, COVID-19


Provided by the European Society of Clinical Microbiology and Infectious Diseases

Quote: The high risk of death for cancer patients with COVID-19 is aging and September 23, 2020 https://medicalxpress.com/news/2020-09-higher -death-cancer-patients-covid- .html

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