Health
Researchers suggest that fructose produced in the brain may be the mechanism that causes Alzheimer’s disease-ScienceDaily
A new study published by the University of Colorado Anschutz Medical Campus suggests that Alzheimer’s disease can be caused by overactivation of fructose produced in the brain.
This study Frontier of Aging Neuroscience He outlined the hypothesis that Alzheimer’s disease is primarily caused by Western culture, which resulted in excessive fructose metabolism in the brain.
This paper brings together an interdisciplinary team of neurologists, neuroscientists, and glucose metabolism experts to provide evidence from extensive data and research conducted in Alzheimer’s disease, with high fructose levels and disease in the brain. Is tied together. It also helps explain the association, such as why diabetes and obesity are associated with an increased risk of Alzheimer’s disease.
“In essence, Alzheimer’s disease proposes that fructose is a modern disease caused by dietary lifestyle changes that can disrupt brain metabolism and nerve function.” Anschutz Medical Campus.
Johnson outlines data showing overactivation of brain fructose metabolism that can cause Alzheimer’s disease. The source of fructose is primarily due to its endogenous production in the brain. Therefore, reduced mitochondrial energy production is hampered by inappropriate neuronal glycolysis, which gradually reduces the level of brain energy required for neurons to remain functional and viable.
“By providing a consistent summary of evidence, we hope to inspire researchers to continue exploring the relationship between fructose in the brain and Alzheimer’s disease.”
In one of the scenarios outlined by Johnson and his collaborators, decreased glucose metabolism increased oxidative stress, resulting in progressive loss of mitochondria, eventually leading to neuronal dysfunction and death. In this scenario, amyloid plaques and neurofibrillary tangles are part of the inflammatory response and are involved in the injury, but not the central cause of the disease. In theory, blocking enzymes in the brain that are involved in fructose production or metabolism may provide new ways to prevent and treat Alzheimer’s disease, Johnson said.
Story source:
material Provided by University of Colorado Anschutz Medical Campus.. Original written by Julia Milzer. Note: The content can be edited in style and length.
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