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Johnson & Johnson’s Covid-19 vaccine evoked an immune response in early-stage studies


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The Covid-19 vaccine elicited an immune response in most people who received injections in a small initial trial and showed an acceptable safety profile, according to a study posted online Friday.

The results of this survey are positive in the results of the Phase 1 study and are one of the vaccines. Main candidate During development, we took another step to prove that it works safely.

The results supported the decision to start J & J Larger late study According to the company, up to 60,000 people provide clearer evidence of whether the vaccine protects people from Covid-19.

Large Phase 3 trials may have initial results by the end of the year or early 2021. If the result is positive, the company says it will seek government approval for emergency use.

J & J in New Brunswick, NJ has begun the first human study of a vaccine codenamed Ad26. COV2. S, in Belgium and the United States in July Register over 1,000 adults..

Various dose levels and dosing regimens were tested in the study subjects.

Detailed provisional Research results Posted on online preprint server medRxiv. This site is reviewed by peer reviewers and publishes medical manuscripts before they are published in medical journals.

Among the majority of the specific subgroups under study, studies have shown that a single dose of vaccine elicited so-called neutralizing antibodies against coronavirus, as measured in blood samples about 4 weeks after vaccination.

Neutralizing antibodies are agents of the immune system that researchers believe can block the virus and ward off Covid-19.

The study said that vaccine-induced neutralizing antibody levels were comparable to those found in the blood of people who recovered from Covid-19. Neutralizing antibody responses among vaccinated people were comparable between young adults and the elderly, he said.

However, early-stage studies did not indicate whether these immune responses interfered with Covid-19. This will be tested in new and larger studies.

Some people in early-stage studies experienced injection site pain, fever, fatigue, headache, and myalgia after vaccination. The researchers said no one stopped participating in the trial because of an adverse event.

Write to Peter Loftus [email protected]

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