Health
Strong activation of antibacterial cells of the immune system associated with severe Covid-19: Study
They explained that T cells are a type of white blood cell that specializes in recognizing infected cells and are an important part of the immune system.
In a current study published in the journal Science Immunology, scientists evaluated the role of MAIT cells in COVID-19 disease.
They examined the presence and characteristics of MAIT cells in blood samples of 24 patients admitted to Carolinska University Hospital with moderate to severe COVID-19 disease and recovered from 14 healthy controls and COVID-19. Compared with blood samples from 45 individuals.
According to a study, four of the patients died in the hospital.
“To find potential treatments for COVID-19, it is important to have a detailed understanding of how the immune system responds, which in some cases can contribute to the exacerbation of the disease.” Said Johann Sandberg, co-author of the research at the Karolinska Institute. ..
Studies show that the number of MAIT cells in the blood drops sharply in patients with moderate or severe COVID-19, and the remaining cells in the circulation are highly activated.
Based on these results, scientists suggested that MAIT cells are involved in the immune response to the novel coronavirus SARS-CoV-2.
They said that this pattern of blood count reduction and activation was stronger in MAIT cells than in other T cells.
The study also noted that pro-inflammatory MAIT cells accumulated more in the airways of COVID-19 patients than in healthy individuals.
“In summary, these analyzes show that the decrease in the number of MAIT cells in the blood of patients with COVID-19 is due, at least in part, to increased accumulation in the airways,” Sandberg said. Stated.
Scientists added that the number of MAIT cells in the blood of convalescent COVID-19 patients recovered at least partially in the weeks following the disease. This is important for managing bacterial infections in individuals with COVID-19.
They said MAIT cells tend to be extremely activated in deceased patients.
“The results of our study show that MAIT cells are very involved in the immune response to COVID-19,” Sandberg said.
Scientists believe that the properties of MAIT cells are early involved in both the systemic immune response and the local immune response of the airways that are replenished from the blood by inflammatory signals.
“Therefore, they are likely to contribute to a rapid innate immune response to the virus. In some people with COVID-19, MAIT cell activation is overactive, which correlates with serious disease.” Sandberg added.
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