Health
Coronavirus can deplete male testosterone levels, according to scientists
Dubai : Low hormone levels can cause a poor prognosis after a positive test for the new coronavirus, according to a new study that COVID-19 disease can exacerbate testosterone levels in men ..
Studies published in the journal Aging manNote that as baseline testosterone levels decrease in men, their chances of being in the intensive care unit (ICU) increase significantly.
According to Selahittin Cayan, a professor of urology at the University of Mersin, the lead author of the study, it has already been reported that decreased testosterone levels may be responsible for a poor prognosis after a positive SARS-CoV-2 test. Is the first study. To show that COVID-19 itself depletes testosterone.
Scientists believe that the findings can explain why men have a worse prognosis than women with COVID-19, and therefore discover the potential for improved clinical outcomes using testosterone-based therapy. Helps to.
They said testosterone is associated with the respiratory immune system and low levels of hormones can increase the risk of respiratory infections.
“Lower testosterone is also associated with infection-related hospitalization and death from all causes in men in ICU patients, so testosterone treatment may have more benefits than improving the outcome of COVID-19. “Cayan explained.
The study found that mean total testosterone decreased as the severity of COVID-19 increased.
“Mean total testosterone levels were significantly lower in the ICU group than in the asymptomatic group. In addition, mean total testosterone levels were significantly lower in the ICU group than in the intermediate care unit group,” Cayan said.
The researchers said mean serum follicle-stimulating hormone levels were significantly higher in the ICU group than in the asymptomatic group.
“Hypongadism, a condition in which the body does not produce enough testosterone), was found in 113 (51.1 percent) male patients,” Cayan said.
Patients who died had significantly lower mean total testosterone than those who were alive, according to the researchers.
However, they said that even 65.2 percent of the 46 male patients who were asymptomatic had “decreased libido.”
Scientists evaluated a total of 438 patients, including 232 men, each confirming SARS-CoV-2 in the laboratory.
They performed a detailed analysis of the patient’s medical history, performed a complete physical examination, and performed laboratory and radiographic examinations on all patients.
The cohort study was divided into three groups: asymptomatic patients (46), symptomatic patients admitted to the internal medicine unit (129), and patients admitted to the intensive care unit (ICU) (46).
In patients (24) who underwent serum gonadal hormone testing prior to COVID-19, scientists stated that total serum testosterone levels were significantly reduced from pre-COVID-19 levels.
“It is advisable to also test testosterone levels when diagnosing COVID-19. In men with low levels of COVID-19-positive sex hormones, testosterone treatment may improve prognosis. Further research is needed. “,” Kayan said.
Citing the limits of the study, the researchers said they did not include controls for patients with conditions other than COVID-19.
They said this was due to restrictions imposed on the hospital where they were monitoring the patient.
Future studies will need to determine the concentration level of ACE2 (angiotensin converting enzyme 2), an enzyme that attaches to the cell membranes of cells in the intestine, in relation to total testosterone levels, researchers say.
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