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Early results show that Moderna’s COVID vaccine is safe and effective in the elderly

 


Along EJ Mandel
Health Day Reporter

Tuesday, September 29, 2020 (HealthDay News)-One of the big questions about the new COVID-19 vaccine is whether it can safely protect the highest-risk people, the elderly.

Currently, the results of an early phase I study of 40 adults over the age of 55 show that one vaccine being developed by pharmaceutical company Moderna has an immune system response similar to that seen in young recipients. It suggests that it induces.

Similarly, the side effects of the vaccine were “mainly mild or moderate severity” and included malaise, chills, headache or pain or discomfort at the injection site.

They published the preliminary findings of September 29th online New England Journal of Medicine..

“Because older people are at greatest risk of severe COVID-19 infection, it’s important to understand how well the vaccine works in this age group,” said a non-trial expert. One Dr. Amesh Adalja explained.

“This early Phase 1 trial seems promising, but we won’t know for sure until Phase 3 data is available,” said Adalja. He is a senior scholar at the Johns Hopkins Health Security Center in Baltimore.

The new study focused on an Moderna vaccine called mRNA-1273. The double-dose vaccine is in late-stage trials, and Moderna says it hopes to make the vaccine widely available by the end of the year.

However, Dr. Bruce Hirsch, Ph.D. infectious disease at Northwell Health in Manhasset, New York, said, “Among the various risk factors, older age has been recognized from the beginning to be associated with poor vaccine outcomes.” Said.

Therefore, “doctors are worried that those who need this vaccine most may be the least responsive to the vaccine,” he said.

To answer this question, a team led by researchers at Emory University in Atlanta specifically examined immune response and side effect data from 40 patients aged 56 years and older enrolled in the mRNA-1273 trial.

Immediately after taking the first shot, they observed a rapid rise in coronavirus-specific immune system antibodies in these elderly people. Their numbers were even higher after the second shots were administered.

Most importantly, the antibody response in the group 55 and older “looked similar to what was previously reported among vaccinated people between the ages of 18 and 55,” the researchers said. Stated.

Other immune system markers, such as levels of proteins called T cells and cytokines, also appeared to be “strong” in response to the vaccine.

Side effects can occur after vaccination, but were similar to those sometimes seen in people vaccinated against the flu. For example, temporary fatigue, chills, headaches.

Dr. Eric Cioe-Pena is an emergency physician at Staten Island University Hospital in New York City. After reading the findings, he agreed, “although the data are limited, this Phase 1 study demonstrates the safety of an important target population, the elderly.”

Nevertheless, Hirsch emphasized that the small scale of the study still means that caution is needed.

“The ability of vaccines to prevent actual infections in the real world has not yet been tested,” said Hirsch. “This study remains unsolved as to how durable immunity is. Preliminary data is this pandemic. “

For more information

The US Centers for Disease Control and Prevention New coronavirus..

Source: Amesh Adalja, MD, Senior Scholar, Johns Hopkins University Health and Security Center, Baltimore. Eric Shioe Pena, MD, Emergency Doctor, Staten Island University Hospital, New York City, Northwell Health Global Health Director. Bruce Hirsch, MD, attending physician, infectious disease, Northwell Health, Manhasset, NY. New England Journal of Medicine, September 29, 2020

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