Health
Cannabinoids associated with adverse respiratory health effects in the elderly with COPD
According to the first published data on the effects of cannabinoids, cannabinoids, a class of prescription drugs containing synthetic chemicals in marijuana, increase mortality in the elderly with chronic obstructive pulmonary disease (COPD) by 64%. Is related to. About the respiratory health of individuals with lung disease.
The findings, published in the chest on Wednesday, have clinical implications as more doctors prescribe cannabinoids to COPD patients to treat chronic myalgia, insomnia, and shortness of breath.
The study, led by St. Michael’s Hospital in Unity Health Toronto, found that cannabinoids can adversely affect respiratory health events in COPD patients, including hospitalization and death. COPD is a progressive lung disease that causes dyspnea and chronic productive cough and may be associated with various non-respiratory problems such as chronic muscle aches and insomnia. ..
“Cannabinoid drugs are increasingly being used by older people with COPD, so it’s important for patients and physicians to have a clear understanding of the side effect profiles of these drugs,” said Nicholas Bozoris, a pulmonologist at St. The doctor says. .Michael’s and Associate Scientist at the Li Ka Shing Knowledge Institute in the hospital.
“Our findings do not mean that cannabinoid drugs should never be used in older people with COPD. Rather, our findings need to be incorporated into prescribing decisions by patients and physicians. If you really need to use these medicines. “
The study analyzed the health data of more than 4,000 individuals in Ontario, 66 years and older, with COPD from 2006 to 2016. The data was evenly divided into two groups. .. Elderly people in Ontario with COPD, a new cannabinoid user, accounted for 1.1% of the data made available by ICES.
Researchers have observed that the health of COPD patients who were using high doses of cannabinoids was particularly deteriorating. Compared to non-users, new high-dose cannabinoid users had a 178% increase in hospitalization for COPD or pneumonia and a 231% increase in death from all causes.
“Elderly people with COPD are a group that is susceptible to cannabinoid-related respiratory side effects. Elderly people cannot break down drugs efficiently, so the effects of drugs can remain in the body for a long time. Patients with COPD “Existing respiratory problems and disorders,” said Dr. Vozoris, an ICES scientist.
Because cannabinoids are often prescribed as an alternative to opioids to treat chronic pain, researchers are investigating how cannabinoids and opioids affect the respiratory outcomes of older people with COPD. We performed a sub-analysis for this. The researchers found no evidence that cannabinoids were a safer choice than opioids for older people with COPD in terms of respiratory health outcomes.
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