Health
ICDDR, B selected from 5 global laboratories to evaluate COVID-19 vaccine
ICDDR, B, the world’s leading health research institute based in Dhaka, the capital of Bangladesh, is working together as part of a centralized network to reliably assess and compare the immune response generated by COVID-19. Selected as one of the five laboratories. Vaccine candidate.
ICDDR, B, a reputed international health research institute, is part of a network of laboratories emerged by the Infectious Disease Control Innovation Coalition.
According to a press release issued by the Norwegian-based CEPI, CEPI will partner with five clinical sample testing laboratories on Friday to build a centralized global network to reliably evaluate and compare vaccine candidates. Announced.
Nexelis (Canada) and Public Health England (PHE, UK), VisMederi Srl (Italy), Viroclinics-DDL (Netherlands and Translational Health Sciences and Technological Institute (THSTI, India)) were first selected for this vaccine evaluation. The other four laboratories. Communication network.
“We commend CEPI’s efforts to establish a centralized laboratory network and are committed to contributing to the network as an organization with decades of experience in vaccine evaluation.” ICDDR, B John Clements, executive director of the company, said in a statement.
The network uses the same test reagents developed in the Nexelis and PHE labs and follows a common protocol for the immunogenicity of multiple COVID-19 vaccine candidates (both CEPI-funded and CEPI-funded developers). To measure. ..
This approach ensures uniformity of evaluation and informed identification of the most promising vaccine candidates, CEPI said, adding that he was actively negotiating with additional laboratories to join the network. ..
According to CEPI, there are several benefits to centralizing the immune response assessment of the COVID-19 vaccine.
Usually, the immunogenicity of a potential candidate vaccine is to determine whether clinical trial volunteers produce biomarkers of the immune response (such as antibodies and T cell responses) after administration of the next dose. He added that the objective would be to be evaluated through individual laboratory analysis. Vaccine candidate.
However, with more than 320 vaccine candidates for COVID-19 currently under development, CEPI states that there are likely to be many differences in the way data is collected and evaluated.
This data includes potential fluctuations in the range of immune correlations measured in the laboratory. Technical differences in the way and location of sample collection, transportation and storage can also occur, affecting the quality and usefulness of the data generated and making it difficult to compare measurements in individual laboratories. ..
In addition, the wide range of approaches and technologies currently being deployed for COVID-19 vaccines has greatly complicated the standard assessment of the true potential of these vaccine formulations, CEPI said.
According to CEPI, by centralizing the analysis of samples from the COVID-19 vaccine candidate trials, a new clinical sample trial network could result from technical differences in conducting independent analyzes. Minimize variability in the results obtained.
Samples from participating vaccine developers are instead tested in the same laboratory group using the same method, eliminating much of the laboratory variability and being triggered by multiple vaccine candidates. Allows direct comparison of immune responses.
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