Health
Dozens of mammals can be susceptible to the Covid virus
Researchers have found that most birds, fish, and reptiles do not appear to be at risk of infection, but most of the mammals they reviewed may be potentially infected.
According to a study published in the journal Scientific Reports, they predicted the potential for transmission of ferrets and macaques infected in all reported cases of domestic cats, dogs, minks, lions, tigers, and laboratory studies. doing. ..
“We wanted to find out which animals were at risk of infection, not just those that were ly studied, to see if further research and possible monitoring were needed,” said a professor at the University College London. Said the lead author, Christine Orengo.
“The animals we have identified may be at risk of outbreaks that could threaten endangered species or harm the lives of farmers. Animals also act as virus reservoirs and later. Can re-infect humans at Mink Farm. ”
In this study, we investigated how the SARS-CoV-2 spike protein interacts with a major cellular receptor in the human virus called angiotensin converting enzyme 2 (ACE2).
The focus of the study was whether 215 animal ACE2 proteins were mutated and differed from the human version, resulting in reduced stability of the binding complex between the viral and host proteins.
When bound to a protein, the virus can invade the host cell. The virus can infect animals via alternative pathways, but is believed to be based on current evidence that the virus can infect animals if it fails to form a stable binding complex with ACE2. not.
Researchers have found that in some animals, such as sheep and apes (chimpanzees, gorillas, orangutans, bonobos, etc., many of which are wild and endangered), proteins bind as strongly as: I found that I could do it. The virus infects humans.
This does not confirm that the animal may actually be infected, as some animals, such as sheep, have not yet been tested for infection.
The research team also conducted a more detailed structural analysis of specific animals to better understand how the risk of infection varies between animal species.
By comparing their findings with other data, they set thresholds for predicting which animals are at risk of infection and which animals are most likely to be infectious.
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