Connect with us


Theoretical models explain the biological phenomena that keep the shape of bacteria


Fat bacteria? Skinny bacteria? From a height point of view, they all seem to be about the same size. In fact, they are.

According to Rice University chemist Anatoly Koromeiski, who currently holds the theory, exactly why it was an open question.

The main mechanism of bacteria is to keep them in the individual Goldilocks zone (that is, just right). It seems to rely on growth and division, two random regulators that cancel each other out. The same mechanism may give researchers a new perspective on diseases, including cancer.

The “minimum model” by Rice’s postdoctoral researcher and lead author Hamid Teimouri and Rupusha Mukelzy, a former research assistant at Rice at the Indian Institute of Technology Gandhinagar, has been published in the American Chemical Society. Journal of Physical Chemistry Letters..

Wherever we see bacteria, they are more or less the same size and shape. The same is true for the cells of our tissue. This is a characteristic of homeostasis, where the system attempts to bring in nearly the same physiological parameters such as body temperature, blood pressure, and blood sugar... “

Rice University Chemist Anatoly Koromeiski

“Nature prefers to put these parameters in a very narrow range so that the living system can function most efficiently,” he said. “Deviations from these parameters are a sign of illness.”

Bacteria are a model of homeostasis, sticking to a narrow distribution of size and shape. “But the explanation so far is not good,” said Koromeiski. “As we know, science doesn’t like magic, but something magical-threshold-is suggested to explain it.”

For bacteria, he said, there is no threshold. “In essence, it’s not necessary,” he said. “There are many underlying biochemical processes, but they can be broadly divided into two probabilistic chemical processes: growth and division. Both are random, so these random phenomena are very deterministic. The problem was to explain why it led to good results. “

Rice Labs specializes in theoretical modeling that describes biological phenomena such as genome editing, antibiotic resistance, and cancer growth. Teimouri said the highly efficient chemical bonds between bacterial growth and division are much easier to model.

“Under typical growth conditions, we assumed that the number of division and growth protein precursors was always proportional to cell size,” he said.

This model predicts when bacteria will divide and allows them to optimize their function. The researchers said it was in good agreement with observations, and that manipulating the formula to knock out bacteria from homeostasis proved their point. They said that increasing the theoretical length of post-mitotic bacteria would reduce their size and simply lead to a faster rate of division.

“For short lengths, growth is dominant and keeps the bacteria in the right size,” Kolomeisky said.

He said the same theory does not always apply to large creatures. “The problem is more complicated because we know that humans have many other biochemical pathways that can regulate homeostasis.”

However, this study may give researchers a new perspective on the growth of diseased cells and, for example, the mechanisms that force cancer cells to vary in shape and size.

“One way to determine cancer is to look at deviations from the norm,” Kolomeisky said. “Are there mutations that lead to faster cell growth or faster division? This mechanism, which helps maintain the size and shape of the bacteria, may help us understand what is happening there. . “


Journal reference:

Teimouri, H. , et al.. (2020) Stochastic mechanism of cell size regulation in bacteria. Journal of Physical Chemistry Letters..


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]