Virtual Steppin’Out in Pink will raise $ 245,000 to support ongoing breast cancer research at Gundersen.Local news

Kenny and his team of talented postdoctoral researchers have made remarkable progress in breast cancer research, tumor sequencing to match patients with the most relevant new drugs, and molecular tumor research.

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In 2016, Kenny’s team successfully used the drug crizotinib, which was initially approved for use in patients with lung cancer, in patients with MET-amplified (metastatic) triple-negative breast cancer. After responding well to chemotherapy, which succeeded in shrinking her tumor by 80%, the tumor appeared in her lungs and did not respond to any further chemotherapy.

The team discovered genetic changes through next-generation sequencing. After consulting with the State Precision Medicine Molecular Tumors Commission, they recommended crizotinib, and the patient survived for a few more months, after which he developed another tumor that did not respond to the drug.

Kenny’s team collects samples from new tumors that have been genetically tested to identify what has changed and caused no response. “Usually, recurrences occur within a few months to a year,” says Kenny, because patients have late-stage cancer with millions of cancer cells. “Like all metastatic cancers, breast cancer is a very difficult cancer.

Kenny and his team reported for the first time in the world the efficacy of crizotinib in patients with triple-negative breast cancer with the MET mutation. Only one in 125 women with breast cancer has a change in MET, so a standard laboratory test that does one gene at a time costs about $ 650 per patient. This will result in spending of over $ 80,000 to find one person who is likely to respond to crizotinib.

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