Health

Teenage brain differences associated with increased hip circumference-ScienceDaily

According to a study funded by the National Institute of Substance Abuse, differences in the microstructure of the nucleus accumbens (NAcc) are areas of the brain that play an important role in the processing of food and other reward stimuli, and obesity in children. Predict the increase in indicators of. Abuse (NIDA) and nine other laboratories, all part of the National Institute of Health.Papers published in the journal today Minutes of the National Academy of SciencesIs based on data from adolescent brain cognitive development (ABCD) studies. The ABCD study tracks nearly 12,000 children until early adulthood and evaluates factors that influence individual brain development and other health outcomes.

The findings from this study provide the first evidence of microstructured brain differences associated with the child’s waist circumference and body mass index (BMI). These differences in cell density microstructure may indicate an inflammatory process caused by a diet rich in high-fat foods.

“We know that childhood obesity is an important predictor of adult obesity and other deterioration of health,” said Dr. Nora D. Volkow, MD, director of NIDA. “These results may extend previous animal studies to reveal a vicious cycle in which diet-related inflammation of the striatal region promotes unhealthy eating behavior and weight gain. Is revealed. “

Evidence from past human imaging studies shows a link between NAcc and unhealthy eating behavior in adults. In this study, researchers leveraged new diffusion MRI imaging techniques to examine the cellular structure of areas that make up the striatal reward pathways in the brain and to investigate imbalanced weight gain in young people.

The study included data from 5,366 ABCD study participants aged 9-10 years at baseline, of which 2,133 returned for a one-year follow-up visit. The average waist circumference of participants used here as a measure of body fat increased by an average of 2.76 centimeters per participant from baseline to one year of follow-up. Using non-invasive MRI techniques, researchers used a marker of NAcc cell density to reflect differences in waist circumference at baseline, with a one-year follow-up of waist circumference. It showed that it predicted an increase.

Because ABCD studies are longitudinal, it is possible to assess whether this association is retained or altered during adolescent development and the factors that may affect this trajectory.

Obesity in the United States affects about 35% of children and adolescents, adversely affects their mental and physical health, and increases mortality. Obese children are more than five times more likely to become obese than adults. Combined with knowledge of the factors that can influence this trajectory, a predictive model of youth weight gain will benefit public health and personal well-being.

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material Provided by NIH / National Institute of Substance Abuse.. Note: The content can be edited in style and length.

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