Health
Pig Coronavirus: A new type of coronavirus that affects pigs can jump from pigs to humans
They said the outbreak of such a disease could cause economic turmoil in many countries around the world that depend on the pork industry.
In a new study published in the journal PNAS, scientists conducted lab tests to assess potential threats to people from SADS-CoV, and the virus was efficient in human liver and intestinal cells, and airway cells. I found it to duplicate in.
“Efficient proliferation of human primary lung and enterocytes indicates that SADS-CoV is a potential high-risk new coronavirus pathogen that can adversely affect the global economy and human health. “The scientists write in their research.
Beta coronavirus that causes respiratory disease COVID-19 in humans Although it belongs to the same virus family as SARS-CoV-2, scientists have stated that SADS-CoV is an alphacoronavirus that causes gastrointestinal disease in pigs. It was.
They said the virus caused severe diarrhea and vomiting, especially for young piglets.
SADS-COV is also different from the two common cold alphacoronaviruses circulating in humans, HCoV-229E and HCoV-NL63.
“Many researchers have focused on the potential emergence of betacoronaviruses such as SARS and MERS, but in reality, alphacoronaviruses have the potential to jump rapidly between species. Concerns about human health may be found to be equally pronounced, “said the collaborative study.Author Ralph Lauren, Professor of Epidemiology UNC-Chapel Hill..
Although SADS-CoV has not previously been known to affect humans, researchers have stated that coronavirus strains found in animals can also infect humans. This is an effect known as the spillover effect.
According to scientists, a wide range of mammalian cells, including primary human lung cells and intestinal cells, are susceptible to SADS-CoV infection, and the virus, unlike the novel coronavirus, has a higher growth rate in the intestinal cells found in the human intestine. It mainly infects lung cells.
Studies suggest that cross-defense immunity often prevents people from being infected with many of the coronaviruses found in animals, but researchers have found that humans have such protection against SADS-CoV. I believe I haven’t developed it yet.
“SADS-CoV is derived from the bat coronavirus called HKU2. HKU2 is a heterogeneous group of viruses distributed around the world,” said Caitlin Edwards, another co-author of the study.
“It is impossible to predict whether this virus, or a closely related HKU2 bat strain, will emerge and infect human populations,” Edwards said.
However, due to the wide host range of SADS-CoV and its ability to replicate in human primary lung and enterocytes, researchers show that the virus “potential risk of future emergence events in human and animal populations.” I think.
Edwards and her colleagues tested the broad-spectrum antiviral remdesivir as a potential treatment for infections, and preliminary results show that it has potent activity against SADS-CoV. I did.
However, scientists have warned that more tests are needed on additional cell types and animals to confirm these findings.
“Promising data from remdesivir provide potential treatment options in the case of human spillover events,” Edwards said.
“It is advisable to continuously monitor both pig workers and pig populations for signs of SADS-CoV infection to prevent outbreaks and major economic losses,” she said. Added.
Surveillance and early isolation of infected piglets provides an opportunity to reduce the potential for larger outbreaks and spillover to humans, but Barrick says vaccines limit future global spread and human emergence events. He said it might be the key to doing so.
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