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Studies suggest that the immune system loses its ability to protect against infection much sooner than expected




According to a new study, the immune system peaks in school-aged children and begins to decline much faster than previously thought.

According to a new study by the London School of Economics and Tropical Medicine, “immune aging” begins in the teens and can increase in severity of many infections by the age of 20. For illnesses, including Covid-19, the increase in severity began later and was discovered by the team to be around the age of 40.

Professor Judith Grin, lead author of the London School of Economics and Tropical Medicine, said: Surprisingly, little is known about how the response to infection changes between these extreme ages. “

In fact, although this study, which includes 142 datasets containing information on the age and severity of illnesses in patients with 32 different bacterial and viral infections before and after the spread of antibiotics and vaccines in a particular condition, was initially investigated. It is one. Lifelong changes in the immune system.

“Our results suggest that the immune response peaks during school age and then begins to decline much earlier than currently thought, and in some cases at age 15,” Glynn said. Stated. “The discovery of’immune aging’may catalyze young adults with a new approach that is highly needed in the design and scheduling of drugs and vaccines. “

Talk to THe is telegraphShe added, “I hope this gives new clues to how to investigate and best respond to infectious diseases. What is a child’s immune system good at and an adult’s bad at?”

By the age of 20, the severity of polio, typhoid fever, tuberculosis, measles, smallpox, chickenpox, HIV, infectious mononucleosis, and yellow fever was high. Scientific data Indicated.

Ebola hemorrhagic fever, meningococcal meningitis, cholera, red fever, and Lassa fever all increased in severity after age 20, and seasonal influenza, brucellosis, and hepatitis B became more severe after age 30.

For Sars, Mers, Covid-19, and hepatitis A, the severity begins to increase at age 40.

Due to the weak immune system at birth, newborns are known to be susceptible to many infectious diseases. However, when exposed to new bacteria and viruses, it is rapidly strengthened. However, with age, the number of cells that can respond to a new infection called naive T cells decreases. This explains in part why the mortality rates of new pathogens like Covid-19 are so high among the elderly who are not ready to repel these cells.

What is surprising in the new study is the suggestion that this aging of the immune system begins to occur very early in life-in one theory, during puberty the body probably sacrifices immunity to energize fertility growth and development. Is to focus on a system that is working well at that time.

Professor Daniel Altman, a professor of immunology at Imperial College London who was not involved in the study, said: Questions such as susceptibility to symptomatic Covid-19. “

“It should be remembered that some of the best antibody-T cell responses to the virus are found in older people, but this group tends to give worse results.”


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