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Studies suggest that people with blood group O may have a lower risk of COVID-19 infection and serious illness

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According to two studies published Wednesday, people with blood group O are less vulnerable to COVID-19 and may be less likely to become severely ill. Experts say further research is needed. This study provides further evidence that blood types (also known as blood types) can play a role in a person’s susceptibility to infection and the likelihood of severe seizures of the disease. The reason for this link is not clear, and more research is needed to say how it affects patients, if any. The study adds to growing evidence A Danish study found that only 38.4% of the 7,422 people tested positive for COVID-19 had blood group O — in a group of 2.2 million people not tested. Among them, its blood type accounted for 41.7% of the population. In contrast, 44.4% of Group A were positive, but in a wider Danish population that blood and other studies, Canadian researchers found that out of 95 patients with COVID-19 severely ill, blood group O Or we found that a higher proportion (84%) of blood group A or AB required mechanical ventilation compared to patients with AB. In a Canadian study, patients with blood group A or AB stayed longer in the intensive care unit than patients with blood group O or B, with a median of 13.5 days. The 9th. “As a clinician … I look at patients and stratify them when it’s behind my mind. But when it comes to definitive markers, I find repeatedly in many jurisdictions that show the same thing. “We need to,” said Dr. Mypinder Sekhon, an intensivist at Vancouver General Hospital and author of a Canadian study. It replaces other risk factors of severity, such as age and comorbidities, “added Sekhon, an assistant professor of critical care and medical school at the University of British Columbia. Group A, no need to panic. And if you have blood type O, you can’t go to pubs or bars freely. “Don’t worry. Most humans fall into one of four blood types: A, B, AB, or O. In the United States, the most common blood types are O and A. Unless you need to transfer your blood type, there is little difference in your daily life, and you don’t have to worry too much about the relationship between your blood type and COVID-19, says Dr. Torben Barington, Denmark. “I don’t know if this is some kind of protection for Group O or some kind of vulnerabilities of other blood types,” said the lead author of the paper and a clinical professor at Odens University Hospital and South Denmark University. I think this has scientific interest. Once you know what the mechanism is, you can probably use it positively in some way for treatment, “said the researchers in a Danish study from February 27. Blood group ratios between Danish and those people tested by July 30 were compared to data from untested people. They found that blood type was not a risk factor for COVID-19 hospitalization or death. Both studies were published in the journal Blood Advances. There are several theories, but researchers do not yet know which mechanism can explain the link between different. Blood type and COVID-19.Sekhon said that people with blood type O can be explained by the fact that they have fewer major coagulation factors and are less likely to have blood coagulation problems. Coagulation was a major contributor to the severity of COVID-19. Other possible explanations include blood group antigens and how they affect the production of antibodies that fight infection. Alternatively, it may be related to blood group-related genes and their effects on receptors in the immune system. “This is an interesting repetitive scientific observation, and further mechanistic research is really needed,” he said. Dr. Ameshua Darja, a senior scholar at the Johns Hopkins University Center, said the new study “rather than blood type may play a role in a person’s susceptibility to COVID infection and the potential for severe COVID-19 attacks. Provides “converged evidence”. Baltimore Health Security Not Participating in Neither Study Another study, published in the New England Journal of Medicine in June, found genetic data for some COVID-19 patients and healthy people. Patients with type blood group were at high risk of infection, and those with type O blood group were at low risk. Earlier genetic research, combined with two new studies from Blood Advances, “suggests that this is a real phenomenon,” said Adalja, who focuses on emerging infectious diseases. “The menon we see,” he said. “It hasn’t reached the point where it’s an iron wall, but it’s clearly suggestive and there’s nothing inconsistent with it. The same pattern appears, type O. Tends to stand out, “says Adalja. Adalja states that blood types and susceptibility to various infections have been previously studied in the medical literature. If the blood type is O, it seems to be susceptible to norovirus infection. Regarding the new coronavirus that causes COVID-19, “To be sure how this is happening, we need to understand the mechanism and at the molecular level. — This is actually type O. It’s not like tracking type O, “said Adalja.” I’ve come to think of this as an important research topic. ” There is still more science to do here, but there seems to be more evidence accumulating on this hypothesis. ”

According to two studies published Wednesday, people with blood group O are less vulnerable to COVID-19 and may be less likely to become severely ill. Experts say further research is needed.

This study provides further evidence that blood types (also known as blood types) can play a role in a person’s susceptibility to infection and the likelihood of severe seizures of the disease. The reason for this link is unclear, and further research is needed to say how it affects patients, if any.

Research adds to growing evidence

According to a Danish study, only 38.4% of the 7,422 people who were positive for COVID-19 had blood type O. However, in the untested group of 2.2 million people, their blood type accounted for 41.7% of the population.

In contrast, 44.4% of Group A are positive, while in Denmark’s wider population, blood type accounts for 42.4%.

In another study, Canadian researchers found a higher proportion of blood group A or AB (84%) of 95 patients with COVID-19 who were severely ill with blood group O or B (61%). %) Found that they needed a ventilator.

In a Canadian study, patients with blood group A or AB stayed in the intensive care unit longer and had a median of 13.5 days compared to patients with blood group O or B with a median of 9 days. I understand.

“As a clinician … it’s deep in my heart to look at and stratify patients, but the definitive markers need to be repeatedly discovered in many jurisdictions that show the same thing.” Said Dr. Mypinder Sekhon. , Intensivist at Vancouver General Hospital and author of a Canadian study.

“I don’t think this will replace other risk factors of severity, such as age and comorbidities,” added Sekhon, an assistant professor of critical care and medical school at the University of British Columbia. Columbia.

“If one is blood type A, you don’t need to start a panic, and if you have blood type O, you can’t go to a pub or bar freely.”

Don’t worry

Most humans fall into one of four blood types: A, B, AB, or O. In the United States The most common blood types are O and A..

Unless you have to do a blood transfusion, there is little difference in your daily life. Dr. Toben Barrington, lead author of the Danish paper and clinical professor at Odense University Hospital and the University of Southern Denmark, said that one should not be overly concerned about the association between blood type and COVID-19.

“I don’t know if this is some kind of protection for Group O or some kind of vulnerability in other blood types,” he said.

“I think this is of scientific interest. Knowing what the mechanism is, it could be used positively in some way for treatment.”

In a Danish study, researchers analyzed data on Danish individuals tested between February 27 and July 30, from people who had not been tested for blood group distribution among those people. Compared with the data. They found that blood type was not a risk factor for COVID-19 hospitalization or death.

Both studies were published in the journal Blood Advances.

There are several theories, but researchers do not yet know which mechanism can explain the link between different blood types and COVID-19.

Sekhon said people with blood type O can be explained by the fact that they have fewer major coagulation factors and are less likely to have problems with coagulation in the blood. Coagulation is a major contributor to the severity of COVID-19.

Other possible explanations include blood group antigens and how they affect the production of antibodies that fight infection. Alternatively, it may be related to genes related to blood type and their effects on receptors in the immune system.

“This is an interesting repetitive scientific observation and we really need more mechanical research,” he said.

“Important Research Question”

The results of two new studies provide “more convergent evidence that blood types can affect a person’s susceptibility to COVID infection and the likelihood of severe attacks of COVID-19.” Johns Hopkins University Health and Security Center in Baltimore. He was not involved in either study.

Another study published in June New England Journal of MedicineFound genetic data in some COVID-19 patients and healthy people, suggesting that patients with type A blood are at increased risk of infection and those with type O blood are at lower risk.

Earlier genetic research, coupled with two new studies from Blood Advances, “suggests that this is the real phenomenon we are seeing,” with a focus on emerging infectious diseases. Adalja said.

“It hasn’t become an ironclad warship, but it’s clearly suggestive and there’s nothing inconsistent with it. The same pattern is emerging and the ABO blood group tends to stand out,” Adalja said. Mr. says. Said.

Adalja said blood types and their susceptibility to various infections were previously studied in the medical literature. For example, studies show that people with blood type O are more susceptible to norovirus infections.

Regarding the new coronavirus that causes COVID-19, “We need to understand the mechanism and understand at the molecular level so that we can say for sure how this is happening. This is actually type O. And it’s like an O-type track with a blood type. “

“We’re starting to understand it now, so I think answering is an important research topic,” he said. “There is more science to be done here, but it seems to me that there is more evidence accumulated about this hypothesis.”

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