Connect with us

Health

Drug discovery targets common to all three coronavirus strains can be used for rapid therapeutic responses to new coronavirus strains-ScienceDaily

Avatar

Published

on


A large international consortium of about 200 researchers from 14 major institutions in 6 countries aims to find these three common vulnerabilities in three different coronaviruses (SARS-CoV-1). , SARS-CoV-2, and MERS-CoV). Pathogen. The study, published in Science, identifies important molecular mechanisms essential for all three coronaviruses and drugs that have the potential to be reused as a pan-coronavirus treatment.

The consortium includes EMBL’s European Bioinformatics Institute (EMBL-EBI), the University of California, San Francisco (UCSF) Quantitative Biological Sciences Institute (QBI) Coronavirus Research Group (QCRG), Gladstone Institutes, and Pastor Research. By the way, researchers from the Cluster of Excellence CIBSS were included. Other collaborators, including Freiberg University, Howard Hughes Medical Institute, and biotechnology companies Aetion and Synthego.

There are three known human respiratory syndromes associated with coronavirus: Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Coronavirus Disease 2019 (COVID-19). These are caused by SARS-CoV-1, MERS-CoV, and SARS-CoV-2, respectively.

Scientists have identified drug discovery targets and reused therapies that may have broad-spectrum activity across all three coronavirus strains. Reused therapies with known safety profiles may provide a rapid therapeutic response to new coronavirus strains in the future.

Identifying coronavirus drug discovery targets

Based on previous works published in Nature And cellScientists have determined how viral and human proteins interact and where the viral proteins are located in different coronavirus-infected host cells. They then used this data and functional genetic screening to identify host factors that prevent the growth of coronavirus. The data analyzed in this study will be freely accessible from the COVID-19 Data Portal.

“These analyzes show how biological and molecular information is translated into actual effects on the treatment of COVID-19 and other viral diseases,” said EMBL-EBI Group Leader. One Pedro Beltrao says. “In the last two decades, after more than a century of relatively harmless coronaviruses, three deadly coronaviruses have emerged. Examining the entire species may be a pandemic that may be effective in treating coronaviruses. We can predict viral remedies. We believe that the current pandemic will also provide promising treatments for future coronaviruses. “

Another Step to Treat COVID-19

The researchers also performed a real-world analysis of clinical data on outcomes in patients with COVID-19. To do this, they identify molecules in human cells that may be targets for FDA-approved therapeutic agents and how these agents affect patients with COVID-19 in the clinic. I looked it up. The analysis involved more than 740,000 patients in the United States with known SARS-CoV-2 infections.

The data and analysis performed in this study show how molecular information is transformed into actual effects on the treatment of COVID-19. This study also presents a collaborative approach that can be applied to study other infectious pathogens in the future.

“This extensive international study reveals for the first time the commonalities of the entire coronavirus, and, importantly, its vulnerabilities, including the current challenges for the COVID-19 pandemic,” said Gladstone, director of QBI. Nevan Krogan, senior researcher at the institute, said. “Bridge biological and functional insights and clinical outcomes in a unique and rapid way, conduct research on all diseases, quickly identify promising treatments, and gain knowledge in both scientific and medical disciplines. We were able to provide an exemplary model of a differentiated way to advance. This series of work is only done in collaboration with senior scientific thought leaders and teams of next-generation researchers from major institutions around the world. It is now possible. “

Financing

This work was funded by grants from the National Institute of Mental Health and the National Institute of Allergy and Infectious Diseases, which are part of the National Institute of Health. Defense Advanced Research Projects Agency; Influenza Cause Research Center; Center of Excellence for Influenza Research and Surveillance at the National Institute of Allergy and Infectious Diseases. Center of Excellence for Integrated Biology of Emerging Infectious Diseases, Agence Nationale de la France (France). F. Hoffmann-Laroche AG; Vir Biotechnology, Center for Integrated Biological Signal Transduction Research (CIBSS), European Research Council (ERC), and Ron Conway family. A complete list of authors and complete funding information Science paper.

..

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos



Pictures Credit

ExBUlletin

to request, modification Contact us at Here or [email protected]