Antibodies made by the body to fight COVID-19 (blood transfusions are being tried as a treatment for other more severely ill patients) decline rapidly after recovery.
Experts from Canada Study blood of recovery Coronavirus Patients found that the degree of immune defense diminished 6 to 10 weeks after the initial symptoms.
Plasma transfusions have not yet been proven as a treatment in randomized trials, but small retrospective studies suggest that it may reduce the severity of the disease.
If so-called “convalescent plasma” proves beneficial, it means that it has a short chance of being donated, researchers warned.
Donors should wait two weeks after their symptoms have subsided before giving blood. This is to ensure that the virus particles are gone. Symptoms usually last two weeks before that.
Given this, the plasma donation time frame may be as short as just two weeks.
Antibodies made by the body to fight COVID-19 (blood transfusions are being tried as a treatment for other more severely ill patients) decline rapidly after recovery.The photo shows a recovering coronavirus patient donating plasma for transfusion to a critically ill patient.
“We don’t want to transfuse the virus, we just transfuse the antibody,” said Andrés Finzi, a dissertation author and virologist at the University of Montreal, Canada.
“But at the same time, our research shows that plasma’s ability to neutralize viral particles has diminished in the first few weeks.”
The key to how SARS-CoV-2 attacks the body is the so-called spike protein, which covers the shell of the virus and allows it to latch and invade cells.
However, the antibodies produced by the immune system bind to the ends of spike proteins, preventing them from adhering to cells and nullifying the virus.
In previous studies, antibodies targeting the coronavirus spike protein peaked in the blood about 2-3 weeks after the onset of symptoms, and the effectiveness of this defense may diminish about 4-6 weeks after the same. It is suggested that there is.
In their new study, Dr. Finzi and colleagues monitored 31 recovering COVID-19 patients and analyzed blood samples taken from each individual at monthly intervals.
For each sample, the researchers measured the levels of antibodies (or “immunoglobulins”) that acted on the coronavirus spike protein and tested their ability to neutralize the virus.
The key to how SARS-CoV-2 attacks the body is the so-called spike protein, which covers the shell of the virus (pictured) and allows it to latch and invade cells.However, the antibodies produced by the immune system bind to the ends of spike proteins, preventing them from adhering to cells and nullifying the virus.
The team observed patient-to-patient variability, but in all cases, the levels of the three major immunoglobulins targeting the viral spike protein binding site were within 6-10 weeks of onset of symptoms. I found it to drop.
Decreased levels of these antibodies also reduced their ability to neutralize the virus, which in turn reduced their potential usefulness in plasma transfusions.
The full findings of this study were published in the journal mBio.
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