Connect with us


Initial data on survival benefits for ALS drug shows




Early treatment with a unique combination of sodium phenylbutyrate and taurulusodiol (called AMX0035) increased the survival of patients with amyotrophic lateral sclerosis (ALS). Blind expansion Phase II Centaur trial.

In CENTAUR, ALS patients were randomized 2: 1 to 3 g sodium phenylbutyrate and 1 g taurulusodiol, or to placebo by mouth or feeding tube. At the end of the study, participants in both groups had the option of taking a combination of sodium phenylbutyrate and taurulusodiol for up to 30 months in an open-label, extended study.

Survival analysis of patients in extended trials showed that patients randomized to sodium phenylbutyrate-taurulusodiol at baseline had a median survival of 6.5 months longer than patients starting with placebo, Massachusetts, Boston. Co-authored with Sabrina Paganoni, MD, General Hospital Muscles and nerves..

“Newly published data suggest that treatment with AMX0035 is relevant as well as functional benefit. As previously reported, But also with the benefit of long-term survival, provides substantial evidence supporting the role of AMX0035 in the treatment of ALS, “Paganoni said. Today’s MedPage.

However, the National Center of Neurology and Neurology and Stroke Director Walter Colossets, MD, were more cautious about the results.

“Long-term data support the initial findings that the initial treatment group progressed slowly, but unfortunately, despite treatment, the disease continued to follow a tragic course,” said Colossets. It was. Today’s MedPage. “Hopefully, sustainable scientific efforts will lead to greater effect sizes of treatment in the future.”

Unlike other therapies under investigation, AMX0035 does not target the root cause of ALS, but it does aim to protect motor neurons. Sodium phenylbutyrate and taurulusodiol may reduce neuronal cell death by blocking stress signals in the endoplasmic reticulum and mitochondria, respectively.It is also combined Investigated in Alzheimer’s disease disease.

Phase II CENTAUR research We evaluated 135 ALS patients, including those taking two FDA-approved ALS drugs, riluzole (Rilutek) or edaravone (Radicava). At the start of the study, 77% of patients used at least one of these drugs and 28% used both.

In the modified ITT population, 69% of participants in the sodium phenylbutyrate-taurulusodiol group and 77% of participants in the placebo group completed the study regimen.

In this study, ALS patients treated with sodium phenylbutyrate-taurulusodiol for more than 6 months had lower functional capacity than patients in the placebo group when measured with the revised ALS Function Assessment Scale (revised edition). Was shown to be slow.ALSFRS-R) Score, but the effect was moderate. Secondary outcomes were not significantly different between the two groups, and the adverse event with sodium phenylbutyrate-taurulsodiol was predominantly gastrointestinal.

A total of 90 CENTAUR participants continued the blind extension. 34 were originally randomized to placebo and 56 were originally randomized to sodium phenylbutyrate-taurulsodiol. Participants and researchers were unaware of the original treatment assignments.

Patients who originally started in the placebo group started the study drug about 7 months later than those who started in the sodium phenylbutyrate-taurulusodiol group. The longest follow-up was 35 months after randomization at CENTAUR, with 18 participants originally randomized to aggressive treatment and 9 participants originally randomized to placebo.

Of all CENTAUR-randomized participants, the risk of death was that of the first randomized participants to sodium phenylbutyrate-taurulusodiol compared to those originally randomized to placebo. Was 44% lower between (HR 0.56, 95% CI 0.34-0.92, P= 0.023) During the follow-up period.

Median survival was 25.0 months (95% CI 19.0-33.6 months) in the group initially assigned to sodium phenylbutyrate-taurulusodiol and 18.5 months (18.5 months) in the group initially randomized to placebo. It was 95% CI 13.5-23.2 months). Sensitivity analysis showed that the benefit of survival was independent of background medication.

The study is limited by its sample size. No survival comparison was made between patients receiving study drug alone and patients receiving placebo alone. The next step in the drug is being discussed and “will depend on ongoing conversations with regulators,” Paganoni said.

Last updated: October 16, 2020

  • Judy George Covering MedPage Today’s neurology and neuroscience news, brain aging, Alzheimer’s disease, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s disease, ALS, concussion, CTE, sleep, pain I am writing about such things. To follow


In addition to the work submitted, Paganoni reported grants from Revalesio, Ra Pharma, Biohaven, Clene, and Prilenia. Collaborators had disclosures of grants with many industries.


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]