Health
Tocilizumab does not relieve symptoms or prevent death in COVID-19 inpatients with moderate illness
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Tocilizumab (Actemra) reduces the need for mechanical ventilation and kills COVID-19 inpatients with moderate illness, according to a new study led by researchers at Massachusetts General Hospital (MGH). I will not prevent it.Studies published in New England Journal of Medicine (((NEJM), Tocilizumab, commonly prescribed for rheumatoid arthritis (RA) and other symptoms, suggests that it may be an effective treatment for patients with exacerbated COVID-19. I am asking questions.
Approximately 15% of COVID-19 patients develop severe cases. These patients usually develop pneumonia. Pneumonia lowers blood oxygen levels and requires hospitalization. This life-threatening condition can be caused by a so-called “cytokine storm,” in which the immune system releases an abnormally large number of inflammatory cells (usually protective), damaging the lungs and requiring treatment. There is evidence to show that. Oxygen supplement..
“Peripheral blood inflammatory markers are elevated at high levels in the sky,” said MGH rheumatologist John H. Stone, MD. NEJM Investigation. Patients with COVID-19 who have elevated levels of a cytokine called interleukin-6 (IL-6) have an increased need for oxygen supplementation. Mechanical ventilation And the risk of dying increases.
Tocilizumab blocks IL-6.Previously carried out stone Clinical trial It led to the approval of tocilizumab to treat another inflammatory condition: giant cell arteritis. Several previous studies have suggested that tocilizumab may benefit patients with COVID-19, but the randomized, double-blind, placebo-controlled control needed to confirm that hypothesis (“Gold”). Standard “) There were no exams.The· NEJM The study, led by MGH researchers and conducted by a group of seven hospitals during the pandemic, was called the Boston Regional COVID-19 Consortium (BACC) bait tocilizumab trial.
The study included high levels of inflammation and at least two symptoms of pneumonia and hypotension in moderately severe COVID-19 inpatients.Oxygen level And heat. Two-thirds of the participants received an injection of tocilizumab and the remaining patients received placebo in addition to standard treatment. Most of the patients involved were oxygenated through the nasal canal or cannula. The main purpose of this study is to prevent tocilizumab from eventually requiring or dying from the recipient the respiratory assistance provided by the ventilator via a tube (intubation) inserted into the mouth. It was to find out if.
The study found that patients treated with tocilizumab, like those who received a placebo injection, were more likely to eventually require intubation or die in 4 weeks. Similarly, the condition of patients in both groups improved or worsened at the same rate.
“It was very clear that the use of IL-6 receptor blockade was not justified for the severe patients we studied,” Stone said. Tocilizumab Administering to patients who have already been intubated has no effect.This drug may help COVID-19 patients whose disease severity is somewhere in between patient For those included in the BACC Bay Trial and already in need of mechanical ventilation, Stone says. Research is underway to address this question.
New England Journal of Medicine (2020). DOI: 10.1056 / NEJMoa2028836
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Massachusetts General Hospital
Quote: Tocilizumab is a moderately ill COVID-19 inpatient (2020) obtained from https: //medicalxpress.com/news/2020-10-tocilizumab-doesnt-ease-symptoms- on October 21, 2020. Does not relieve symptoms or prevent death (October 21) death.html
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