Experts warn that certain COVID-19 vaccines can leave people more vulnerable to HIV

A group of researchers At least 4 of the latest batches of the new COVID-19 vaccine Taking clinical trials can make people more susceptible to HIV.

August, one of the vaccine candidates Passed Phase 2 trial And I’m trying to get it widely Phase 3 review In Russia and Pakistan.

The warning comes from a team of scientists led by Professor Susan Buchbinder of the University of California, San Francisco, who is leading HIV prevention research at the Department of Public Health in San Francisco.

The team directly encountered a related issue while working on the production of an HIV vaccine.

Despite 20 years of research, their most successful candidates have backfired. As a result, patients are much more susceptible to the disease.Scientists talk about their “attention” Lancet..

“We are concerned about the use of Ad5 vectors for vaccination. SARS-CoV-2 Similarly, it may increase the risk of HIV-1 infection in vaccinated men. ” They wrote..

(Photo: Jane Barlow-WPA Pool / Getty Images)
Glasgow, Scotland-February 19: Clinical support engineer Douglas Condy extracts the virus from a cotton swab sample and the virus is tested at the Coronavirus Testing Lab at the Royal Glasgow Clinic in Glasgow, Scotland, on February 19, 2020. Allows analysis and identification of genetic structure. ..

How clinical trials can cause HIV

Vaccination requires a kind of vehicle to get to the right place. This is called a vector and this aspect of the vaccine creates fear.

Some coronavirus vaccine applicants use adenovirus as these vectors.For example, in one the studyThe genetically engineered virus provided the coronavirus spike protein genetic code. Therefore, the immune system can learn to identify spikes, SARS-COV-2, as invaders.

Adenoviruses are usually harmless, except to induce the common cold, and other vaccinations effectively use their numerous updated forms as vectors without showing an increased risk of HIV. ..

However, a vector named Ad5 (Recombinant Adenovirus Type 5) is being used by four candidate coronavirus vaccines that have caused problems with HIV vaccines.

When Buchbinder and her collaborators attempted similar protection against HIV 10 years ago, men could become infected with HIV, as a result of two experiments, especially if they had been infected with Ad5 in the past. Has become higher.

The mechanism behind this is still unknown, but a study in 2008 Shows It may be related to the increased activity of the immune system, which increases the number of cells that HIV invades.

In 2014, report Anthony Fauci, led by immunologist Anthony Fauci, cautioned against using this vector in vaccination of HIV-positive areas.

“This important safety consideration needs to be thoroughly evaluated before further development of the Ad5 vaccine for SARS-CoV-2.” Lancet Correspondence Conclusion..

Vaccine makers remain “attention” to these complications

However, these vaccination companies say they are aware of this concern and are considering the threat.

ImmunityBio Was told Science That the Ad5 vector was genetically “muted” to reduce the level of immune response it causes. They plan to try it in South Africa next, if the trial in California is successful.

Glenda Gray, head of the South African Medical Research Commission, who worked with the author of Lancet’s letter on HIV vaccination, said avoiding this vector may not be the right option.

“What if this vaccine is the most effective vaccine?” She asked Science. She said national experts must be allowed to make their own decisions.

The positive news is that this possibility is being addressed in the scientific community. This is a kind of side effect that research helps us understand.

They have an incredible reputation that vaccination is extremely safe after undergoing clinical trials. This active research process worked to address the issue of vaccines until it was announced in the case of Buchbinder’s HIV vaccine.

Research teams around the world are working tirelessly to ensure that this is actually used in the production of the COVID-19 vaccine. Several vaccine experiments to reassess safety issues have been discontinued so far.

Read again: According to scientists, HIV and antivirals have side effects in coronavirus patients and do not cure them.

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