Health
Severe coronavirus infections may provide longer lasting immunity: studies
Toronto-A new study shows that patients with severe COVID-19 infections may be better protected after illness than those with mild symptoms.
The· Learn from King’s College London In the United Kingdom, the immune response to COVID-19 weakened in the first 3 months after infection, and the duration of immunity was found to correlate with the severity of infection.
The study found that patients who experienced a more severe COVID-19 infection may be protected longer than those who experienced mild symptoms. Researchers say the rate of immune response is similar to that of seasonal coronaviruses in other endemic diseases such as influenza.
“The kinetics of the neutralizing antibody response is typical of acute viral infections, with a decrease in neutralizing antibody titers observed after the first peak, indicating that the magnitude of this peak depends on the severity of the disease. “The researchers wrote in their research.
The findings were published in Nature Microbiology on Monday.
People infected with SARS-CoV-2, the virus that causes COVID-19, provoke an immune response to the virus, but the researchers behind the study want to better understand how long that immune response lasts. I was thinking.
For three months, the researchers studied the antibody response of 59 patients and 37 healthcare professionals who were COVID-19-positive and showed signs of symptoms at the Guys and St. Thomas NHS Foundation Trust in London.
This study, typical of acute viral infections, reported that a patient’s antibody response peaked about 1 month after the onset of symptoms and then began to decline.
Data show that people with severe symptoms showed the strongest antibody response, which diminished, but neutralizing antibodies were detectable more than 60 days after the onset of symptoms.
Patients with mild symptoms also elicited an immune response, but studies showed that it was smaller and declined towards baseline levels. For example, some healthcare professionals did not have a detectable immune response within the same follow-up period.
It has been reported that the antibody response to other human coronaviruses also declines over time. This study shows that antibody responses to endemic seasonal coronavirus can last for only 12 weeks, whereas antibodies to SARS and MERS can be detected even 12 to 34 months after infection. ..
Researchers say the findings, which provide insight into the body’s response to the new coronavirus, will have a significant impact on future vaccine design and disease management.
The study points out that the COVID-19 vaccine needs to produce a “robust, long-term immune response” similar to that produced in critically ill patients. The authors added that additional doses of the vaccine may also be needed on a regular basis.
“This study has important implications when examining extensive serological testing and antibody protection against SARS-CoV-2 reinfection, and the need for vaccine boosters to provide long-term protection. May suggest, “the study said.
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