Health
Italy holds human trial of osteoporosis drug to treat COVID-19, world news
Human clinical trials for raloxifene, a generic osteoporosis drug that researchers hope to help reduce the symptoms of COVID-19 and reduce infections in patients, will soon begin in Italy.
Italy’s major drug regulators issued a go-ahead for such trials on Tuesday.
The drug has been identified as a potential COVID-19 treatment by researchers who use supercomputers to screen over 400,000 molecules for chemical properties that may inhibit the virus. It focuses on those that are already approved for use in humans.
Researchers hope that raloxifene, a generic drug known as a selective estrogen receptor modulator, will block the replication of the virus in cells, thereby slowing the progression of the disease.
Early in the coronavirus pandemic, there was some evidence that estrogen present in premenopausal women may have protective effects against the virus. Some scientists believe that raloxifene, which is prescribed to strengthen the bones of older women with low levels of the female hormone estrogen, may provide the same type of protection.
The trial will initially enroll 450 hospitals and home patients at Spallanzani Hospital in Rome and Humanitas in Milan.
They will be treated with raloxifene capsules for 7 days in a randomized sample, with the potential for an additional 174 additional people in the final stages. Registration lasts 12 weeks.
The Excalate4Cov platform, supported by the European Commission, coordinates supercomputing centers in Italy, Germany and Spain with pharmaceutical companies and research centers such as the University of Leuven, Fraunhofer Institute, Politecnico di Milano and Spalanzani Hospital. I am.
With a chemical library of 500 billion molecules, it can process 3 million molecules per second using four supercomputers over 122 petaflops. This is a unit of calculation speed equivalent to 1,000 trillion floating-point operations per second.
Researchers used the power of supercomputers to create three-dimensional structures of twelve coronavirus proteins and run simulations to see where the proteins could be attacked by drugs. ..
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