Health
New heart patch improves recovery from heart attack in rats and pigs
According to the American Heart Association, heart disease has become a leading cause of death worldwide in recent years. During a heart attack, or myocardial infarction (MI), occluded arteries and the resulting oxygen deficiency cause massive cardiac cell death, angiopathy, and inflammation.Now the researchers ACS Biomaterials Science and Engineering We have developed a cardiac patch with small artificial blood vessels that improves recovery from MI in rats and pigs.
To effectively treat MI, it is necessary to regenerate lost myocardial tissue and form new blood vessels to return oxygen and nutrients to cells. Scientists have sought to develop patches containing various therapeutic cells to treat MI, but so far most have been cumbersome to create or with the myocardium to the site of injury Does not restore both blood supplies. Ke Cheng et al. Previously developed a relatively easy-to-create pre-angiogenic cardiac patch containing artificial microvessels within a fibrin gel that spiked cardiac stromal cells.
When transplanted into rats after MI, the cells in the patch secreted growth factors and regrown myocardium and blood vessels. Now, the researchers wanted to test the patch further in rats as well as in pigs, which have a more human-like cardiovascular system than rodents.
Researchers transplanted a heart patch into a rat that had a recent heart attack. After 4 weeks, the patched rats had less scar tissue, increased myocardium, and improved cardiac pumping function compared to untreated rats. The team observed similar effects in pigs that received MI and were treated with patches. The patch increased the recruitment of porcine progenitor cells to the injured area, promoted the growth of new blood vessels, reduced cardiac cell death, and suppressed inflammation.
Previous studies used angiogenic cells or natural blood vessels to angiogenize cardiac patches, but this study used microengineered synthetic blood vessels to treat MI in large animal models. This is the first study to demonstrate the success of a pre-angiogenic cardiac stromal cell patch.Mechanism, safety and Effectiveness of Researchers say patches need to be repaired before the technology can be applied to humans.
Source:
Journal reference:
Sue, T. , et al. (2020) Cardiac stromal cell patches integrated with artificial microvessels improve recovery from myocardial infarction in rats and pigs. ACS Biomaterials Science and Engineering. doi.org/10.1021/acsbiomaterials.0c00942..
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