Health
Studies show that statins can have adverse effects on certain organs
600,000 Danes are taking medications containing statins. Statins lower cholesterol levels and help prevent cardiovascular disease and blood clots. But coins have another side.
Treatment with statins can also have negative side effects, some of which are so severe that people suffering from high cholesterol choose to discontinue treatment. One of the main side effects is muscle soreness, also known as muscle soreness, which can lead to poor quality of life, pain, and pain-induced inactivity.
Statins block the production of cholesterol in cells, but they also block important components of energy production in the cell’s mitochondria. Mitochondria are small energy-producing organelles found in almost every cell in the body. Statins are suspected of lowering intracellular energy levels and causing muscle pain in muscle cells.
Therefore, researchers wanted to find out if statins also inhibited energy production in blood cell mitochondria. And studies from the Health and Aging Center of the Faculty of Health Sciences show that statins do not have the expected effects.
Long-term treatment with recommended doses of statins has been shown to increase the energy-producing capacity of blood cells. These are amazing results. I expected statins to behave like muscle cells, but in fact they do the exact opposite here. “
Lene Juel Rasmussen, Secretary-General and Professor, Health Aging Center, Faculty of Health Sciences, University of Copenhagen
Statins can be good or bad
Surprising results disagree with the theory that statins lower energy levels, but this does not necessarily mean that statins do not adversely affect some organs.
The result is that it doesn’t say anything about whether statins are the cause of affecting energy levels, or whether it’s the body that does it to compensate for the changes caused by statins.
“Statins are very mysterious because they can have both positive and negative consequences depending on the part of the body,” says Rene Yuel Rasmussen.
“Our results show an increase in blood cell energy levels, but we can’t say whether it’s good or bad. It’s that statins improve the energy-producing capacity of blood cells. This can mean that it’s a good thing, or that statins cause damage, and as a result, the body raises energy levels to repair the damage, “she explains.
Different effects on different parts of the body
The mechanism behind the effects of statins on the blood remains unclear, but new results provide entirely new insights into the effects of statins. Unexpectedly, statins behave differently in different parts of the body.
“Previous studies have suggested that statins have potentially beneficial effects on some forms of cancer, and perhaps on some forms of dementia. Statins on different parts of the body. If you can generate new knowledge about the effects, you can use this knowledge to design drugs based on beneficial effects. For example, if statins have a positive effect on the brain, dementia drugs. You can focus on using statins in your design, “explains Rene Juel Rasmussen.
Source:
Journal reference:
Durhuus, JA, et al.. (2020) Simvastatin improves mitochondrial respiration in peripheral blood cells. Science report.. doi.org/10.1038/s41598-020-73896-2..
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