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Cognitive Disorders May Increase Risk of Severe Covid-19: Study: Tribune India

Cognitive Disorders May Increase Risk of Severe Covid-19: Study: Tribune India

 


New York, October 30

Researchers claim that dementia and other cognitive deficits appear to be risk factors for developing severe Covid-19.

The findings, published in the journal Brain, Behavior and Immunity, highlight the need for special care for these pre-existing populations during a pandemic.

“We took a hypothetical approach, and the most statistically significant are cognitive impairment and type 2 diabetes,” said Kaixiong Ye, senior research author at the University of Georgia, USA.

“At this point, we don’t know the mechanism behind these associations, we just know that they are more common in Covid-19 patients,” Ye added.

In a blinded trial, researchers analyzed data from nearly 1,000 illnesses and two specific genes to compare the health profile of Covid patients with those who were test-negative and looked for commonalities among the patients. ..

This study relied on data from UK Biobank. This is a long-term study of more than 500,000 participants investigating the respective contributions of genetic predisposition and environmental exposure to the development of the disease.

The team analyzed genetic factors that increased the risk of severe Covid-19 in some individuals and found two genes, ACE2 and TPMPRSS2, that are known to be important for the virus to invade human cells. I focused on it.

“We found that certain genetic variations in the TMPRSS2 gene were more common in Covid-19 patients,” Ye said, although the discovery was novel at the time, but the team is now genetically host. I know there is more data about the factors. Even 3 months ago.

The researchers also found that mutations in genes associated with SARS-CoV-2 infection may be associated with severe Covid-19 requiring hospitalization.

“And we are beginning to understand how those genetic variations make a difference,” you emphasized.

“Working on one disease is converging the whole field at the same time around the world, which really shows the power of science,” he said.

“My group is actually only doing data analysis and large-scale data mining, but scientists are attacking the disease in many ways, from vaccine development to patient research, Covid. We are moving us very quickly in the fight against -19, “the author of the study wrote.

–IANS

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