Aspirin consumers were less likely to be placed in Intensive Care Unit (ICU) Or they were connected to a ventilator and were more likely to survive the infection than inpatients who were not on aspirin.
Published in the journal Anesthesia and Analgesia, this study “cautious optimism” about cheap and readily available drugs with well-known safety profiles that may help prevent serious complications. Researchers say they are providing it.
“This is an important finding that needs to be confirmed through randomized clinical trials. If our findings are confirmed, aspirin will be the first widely available over-the-counter drug to reduce mortality in COVID-19 patients. It will be, “says the study. Leader Jonathan Chow, MD, Associate Professor of Anesthesiology at UMSOM.
To carry out the study, Dr. Chow and his colleagues screened medical records of 412 COVID-19 patients, an average of 55 years old, who were hospitalized over the past few months for complications of the infection.
They were treated at the University of Maryland Medical Center in Baltimore and three other hospitals along the East Coast. About a quarter of patients took low doses of aspirin (usually 81 milligrams) daily before or shortly after admission to manage cardiovascular disease.
Researchers have found that aspirin use is associated with a 44% reduction in the risk of ventilator placement, a 43% reduction in the risk of entering the ICU, and most importantly, a 47% reduction. discovered. The risk of dying in the hospital compared to those who did not take aspirin. Patients in the aspirin group did not experience a significant increase in adverse events such as major bleeding during hospitalization.
The researchers managed several factors that could have affected the patient’s prognosis, including age, gender, obesity index, race, hypertension, and diabetes. They also described the use of beta-blockers to control heart disease, kidney disease, liver disease, and blood pressure.
COVID-19 infections increase the risk of dangerous blood clots that can form in the heart, lungs, blood vessels, and other organs. In rare cases, thrombotic complications can cause a heart attack, stroke, multiple organ failure, and even death.
Doctors often recommend low-dose daily aspirin for patients who have had a heart attack or stroke previously caused by a blood clot to prevent future blood clots. However, daily use may increase the risk of major bleeding and peptic ulcer.
“We believe that the anticoagulant effect of aspirin benefits patients with COVID-19 by preventing the formation of microclots,” said Michael A., associate professor of anesthesiology at UMSOM, co-author of the study. Dr. Mazzeffi said.
“Patients diagnosed with COVID-19 may want to consider taking aspirin daily, as long as they first check with their doctor,” Mazzeffi added.
For example, a person at high risk of bleeding due to chronic kidney disease, or who regularly uses certain medications such as steroids and anticoagulants, may not be able to take aspirin safely, he said. Added.
Researchers at Wake Forest School of Medicine, George Washington University School of Medicine, Northeast Georgia Health System, and Walter Reed National Military Medical Center also participated in the study.
“This study adds to the tremendous work our researchers are doing in medical school to find new treatments for COVID-19 and save patients’ lives,” said Executive Vice President of Healthcare. E. Albert Reese, MD, said. Affairs, UM Baltimore, and John Z. And Akiko K. Bowers is a prominent professor and dean of the University of Maryland School of Medicine.
“Confirmation studies are needed to prove that the use of aspirin leads to better results for COVID-19, but the evidence so far is that even if patients take aspirin to prevent serious complications. It suggests that you may want to discuss with your doctor whether it is safe or not. “Reese added.
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