Health
MS drugs almost halve the risk of severe Covid symptoms in hospitalized patients
New trials show that drugs used for multiple sclerosis can reduce the chances of developing severe coronavirus symptoms in hospitalized patients by almost half and prevent death.
Covid patients in nine hospitals, including Southampton General, were initially ill after receiving an inhaled version of interferon beta 1a, but could recover within 14 days, twice as much as patients in the placebo group in the study. ..
In a study of 101 patients, three people died in the control group, but none of them were given the drug, despite the need for much more oxygen therapy at the start of the study. Did not die.
In the placebo group, 11 patients (22%) developed severe illness (studies define mechanical ventilation as required) and 6 of 48 patients in the treatment group (13). Person cent).
Researchers are calling for larger trials, but the drug says it may help inpatients fight serious illnesses and recover faster, and also relieve pressure on the NHS. ..
Professor Tom Wilkinson of the University of Southampton, the lead author of the study, said: “The results show that interferon beta, a well-known drug approved for use as an injection for other indications, restores the immune response in the lungs and accelerates recovery from Covid-19.
“Inhaled interferon beta-1a provides a high local concentration of immune protein and enhances lung defense rather than targeting specific viral mechanisms.
“This is an additional benefit of treating Covid-19 infections when they occur in parallel with infections with other respiratory viruses that may be encountered in winter, such as influenza and respiratory syncytial virus (RSV). May bring about. ”
Interferon beta is a naturally occurring protein that regulates the body’s immune response to viral infections.
Although laboratory studies have shown that coronavirus directly suppresses the release of interferon beta, clinical trials have shown reduced activity of this important protein in Covid-19 patients.
This study is published in the journal The Lancet Respiratory Medicine.
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