Health

Leveraging public data reveals new information about genetic and epigenetic changes and their role in cancer-ScienceDaily

A new study led by researchers at the University of California, Irvine, provides a better understanding of epigenetic mechanisms in tumorigenesis and reveals a previously undetected repertoire of cancer driver genes.The study was published this week Science Advances..

Using a new predictive algorithm called DORGE (discovery of oncogenes and tumor suppressor genes using genetic and epigenetic features), researchers have found new tumor suppressor genes (TSGs) and tumor suppressor genes (OGs), especially It could be identified by integrating those with rare mutations. The most comprehensive collection of genetic and epigenetic data.

“Existing bioinformatics algorithms are not able to take full advantage of epigenetic features to predict cancer driver genes, even though epigenetic changes are known to be associated with cancer driver genes. “No,” said Dr. Wei Li, senior author and chairman and professor of Grace B. Bell. Bioinformatics in the Department of Biochemistry, UCI School of Medicine. “Our computational algorithms integrate public data on epigenetic and genetic alternation to improve prediction of cancer driver genes.”

Cancer results from the accumulation of important genetic changes that upset the balance between cell division and apoptosis. Genes with “driver” mutations that affect cancer progression are known as cancer driver genes and can be classified as TSG and oncogene OG based on their role in cancer progression.

This study showed how the cancer driver genes predicted by DORGE contained both known and novel driver genes not reported in the current literature. In addition, researchers found that the novel dual-function genes that DORGE predicted as both TSG and OG are highly enriched at the protein-protein interaction (PPI) and drug / compound gene network hubs. did.

“Our DORGE algorithm leveraged public data to discover genetic and epigenetic changes that play an important role in gene dysregulation in cancer drivers,” explained Li. “These findings may help improve future cancer prevention, diagnosis, and treatment efforts.”

Story source:

material Provided by University of California-Irvine.. Note: The content can be edited in style and length.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit