Health
According to scientists, steroid treatment should be reserved for the most ill COVID-19 patients: Tribune India
Washington, November 15th
Studies suggest that steroids such as dexamethasone should be reserved for the most ill patients, and that most adults with moderate to severe COVID-19 are new coronaviruses rather than life-threatening hyperinflammation. The immune response to is suppressed.
Scientists, including scientists at St. Jude Children’s Research Hospital in the United States, assessed levels of immune system protein cytokines and other health markers in 168 adults with COVID-19, 26 adults with influenza, and 16 healthy volunteers. Did.
They said that more than 90% of COVID-19 patients were hospitalized, about half were hospitalized in the intensive care unit (ICU), more than half of influenza patients were hospitalized for treatment, and 35% were in the ICU. It was.
According to a study published in Science Advances, less than 5% of COVID-19 patients, including some of the most ill, showed a life-threatening hyperinflammatory immune response known as cytokine storm syndrome. ..
Researchers have explained that cytokine storms occur when excess or abnormally regulated levels of cytokine proteins in the body lead to hyperinflammation and tissue damage.
Dexamethasone and other steroids are prescribed to treat cytokine storms, but they said these drugs could be counterproductive in patients with already suppressed immune responses.
“We have identified a subset of COVID-19 patients whose cytokine sequences are widely up-regulated, but overall, the average person with COVID-19 is higher than the average person with inflammation. There was less inflammation, “said Paul Thomas of St. Jude Children’s Research Hospital, co-author of the study.
Based on the findings, scientists said that treatments that suppress inflammation may only be effective in a small number of patients with a hyperinflammatory profile.
They believe that the need for time is a fast, reliable, and inexpensive test for measuring cytokines and identifying patients who are most likely to benefit from dexamethasone treatment.
“Directing immunosuppressive therapy to a small subset of COVID-19 patients with an overactive immune response is the only way to know if these approaches will ultimately help,” another University of Washington study said. Co-author Philip Mad said. American medicine. PTI
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