New compounds identified that may treat the novel coronavirus’

Researchers have discovered new drug compounds that target proteins that allow the new coronavirus to replicate in human cells. (Reuters image)

Researchers have discovered new drug compounds that target proteins that allow new, potentially pandemic coronaviruses and other viruses to replicate in human cells. This is an advance that may lead to new treatments for COVID-19. According to researchers, including researchers at the University of Maryland in the United States, these compounds disrupt the function of protein complexes in human cells that are important for the replication and survival of coronaviruses, including those that cause COVID-19. ..

Scientists believe that the findings published in the journal PNAS could lead to the development of new broad-spectrum antivirals targeting viruses such as influenza and Ebola and coronaviruses such as SARS-CoV-2. I have. They said the compound could disrupt the human SKI protein complex, which regulates various aspects of cell function.

In current research, researchers have also found that this complex also plays an important role in helping the virus replicate its genetic material, RNA, in infected cells. Matthew Frieman of the University of Maryland, co-author of the study, said:

“We have also identified compounds that target the SKI complex and block not only the coronavirus, but also the influenza and filoviruses that cause Ebola,” Freeman said. Using computer modeling, researchers identified the binding site of the SKI complex and identified compounds that could attach to this site.

From further analysis, they showed that these compounds have antiviral activity against filoviruses such as coronavirus, influenza virus, and Ebola. “These findings are an important first step in identifying new antiviral drugs that could be used to treat a number of deadly infections,” said the University of Maryland’s lead author. One Stuart Weston said.

Scientists added that such drugs have the potential to treat future pandemic-related infections.

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