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Covid-19 Respiratory Failure Not Caused by Cytokine Storms: Study newkerala.com # 198934
New York, November 15: A study by the University of Washington School of Medicine in St. Louis and the St. Jude Children’s Research Hospital in Memphis, Tennessee found that only 4% of Covid-19 patients had “ultra-high levels of immunity,” so-called “cytokines.” “Molecular” which means “storm”.
The cause of most cases of respiratory failure in Covid-19 patients remains unknown because cytokine storms are largely excluded.
The researchers analyzed immune cells and molecules in blood samples from 168 Covid-19 patients, 26 influenza patients, and 16 healthy people. Samples were taken from influenza patients in 2019 or 2020, and this year’s Covid-19 patients and healthy controls.
They also collected information about how each patient carried (whether the patient needed intensive care or mechanical ventilation) and whether he or she survived, Xinhua News Agency reports. ing.
The number of inflammatory cells in the blood of Covid-19 and influenza patients was about the same.
7-4% of Covid-19 patients showed signs of cytokine storms, showing very high levels of cytokines even when compared to other critically ill patients.
The majority of Covid-19 patients with acute respiratory distress were not only free of cytokine storms, but also less inflamed than similarly ill influenza patients.
Several clinical trials have shown that some severely ill Covid-19 patients improve on steroids such as dexamethasone, which suppresses inflammation. The important thing is to find a way to identify people at high risk for cytokine storms when they first arrive at the hospital.
Subjects in a cohort with a “true” cytokine storm phenotype have such outliers immunologically compared to other subjects, and there are significant differences in the multiple immune pathways driving this phenotype. Seems like, “said co-author Paul Thomas.
“The ability to characterize these pathways that can be rapidly assessed in the clinical setting may help to stratify patients.”
“In the population we surveyed, 24% died, but only 4% had cytokine storms,” said Philip Mad, an assistant professor of emergency medicine who sees patients at Burns Jewish Hospital. I am.
“Most people who died of Covid-19 died without a cytokine storm. Severe flu is more inflammatory than severe Covid-19. So what causes their lungs to fail? We? I don’t know yet. We are trying to find out. “
Covid-19 Respiratory Failure Not Caused by Cytokine Storms: Study
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