Antiparasitic drug ivermectin kills coronavirus in 48 hours

Around the world, scientists are competing to develop vaccines and treatments for coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Now, a team of researchers has discovered that drugs already available around the world can kill coronavirus in a lab environment in just 48 hours.

Color scanning electron micrograph of apoptotic cells (green) strongly infected with SARS-COV-2 virus particles (yellow) isolated from a sample from a patient with a novel coronavirus SARS-CoV-2. Image taken at the NIAID Integrated Research Facility (IRF) in Fort Detrick, MD. Credit: NIAID

Medicine, IvermectinIs a parasite remedy, an inhibitor of the virus SARS-CoV-2 in vitro, and can effectively reduce the virus in 48 days of cell culture. FDA-approved drugs can be used to divert to treat patients affected by COVID-19 that have spread to 184 countries and territories.

Researcher at Monash University in Melbourne, Australia publishes research in journal Antiviral research, Shows how this already widely used drug can help combat the current global pandemic spill over continents.

COVID-19 viral RNA reduction

The team worked with Peter Doherty Institute of Infection and Immunity. They showed that ivermectin reduced COVID-19 viral RNA present in cell culture by 93 percent at 24 hours and 99.8 percent at 48 hours, and coronavirus RNA by about 5,000-fold. Virus.

“ It has been found that a single dose essentially removes all viral RNA by 48 hours and significantly reduces it even at 24 hours, ” said Dr. Kylie Wagstaff of the Monash Biomedical Discovery Laboratory. Was.

“Ivermectin is so widely used and considered a safe drug. We need to know right now if a human-useable dose is effective. This is the next step,” said Dr. Wagstaff. Was.

Researchers have warned, however, that the tests performed in the study are in vitro and human tests still need to be determined efficacy Drug safety against coronavirus. Ivermectin has also shown in vitro efficacy against a variety of other viruses, including influenza virus, zika virus, and human immunodeficiency virus (HIV).

Diversion of ivermectin

Ivermectin is an approved drug for the treatment of rosacea, head lice, scabies and other parasitic diseases. Developed in 1975, it has been widely used around the world since the early 1980s.

“If there is a global pandemic and there is no approved treatment, if there is already a compound available worldwide, it may help people faster. In reality, a while ago Vaccines are widely available, “explained Dr. Wagstaff.

The mechanism of action of ivermectin on coronaviruses is still unknown, but the drug works on other viruses so that host cells do not interfere with their ability to detect and fight them.

Therefore, ivermectin needs to be further investigated for potential benefits in humans. Further testing is needed to confirm that the drug is effective. If the coronavirus is effective in humans, it is already approved by the U.S. Food and Drug Administration (FDA) and can be widely used to treat affected people.

Country works on COVID-19

Many countries are not ready for the arrival of coronavirus disease in China in December 2019. Since then, it has spread to most countries around the world, and to all continents except Antarctica.

It is reported to be the most infected in the United States, with more than 368,000 people infected with the virus. It gives a phenomenal 10,923 deaths. Italy has the highest number of deaths, with 16,523 fatalities, and more than 136,000 confirmed cases and 13,341 deaths in Spain. More than 16,000 cases have been identified in Canada, and more than 103,000, 98,000 and 82,000 cases in Germany, France and China, respectively.

Coronaviruses have also dramatically affected the UK and Australia, with more than 52,000 and 5,700 cases, respectively.

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