COVID study: Antibodies show potential to neutralize SARS-CoV-2 mutants

By NewsDesk @ bactiman63

Abpro Corporation today announced that it will publish a peer-reviewed article in a scientific journal. Nature communication The title was “Characterizing Neutralizing Antibodies with Prophylactic and Therapeutic Effectiveness Against SARS-CoV-2 in Rhesus Monkeys”.Publications available Online here..

Called MW05 in the publication, ABP300 neutralizes COVID-19 by binding to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, a virus with the angiotensin converting enzyme 2 (ACE2) receptor. Block the interaction. Due to this mechanism of action of the host, which is important for viral invasion and infection, ABP 300 not only completely and safely neutralizes the animal model COVID-19, but is also safer than other monoclonal antibodies under development. It may be possible to neutralize with effectiveness.

“We are greatly encouraged by this preclinical best-in-class proof-of-concept data showing that monoclonal antibodies have the potential to neutralize multiple SARS-CoV-2 strains. This data is for COVID-19. We support the further development of antibody-based therapies for prophylactic and therapeutic treatments, “said Ian Chan, Chief Executive Officer and Co-Founder of Abpro Corporation. “There is an urgent need for treatments that can address a wide range of strains, as SARS-CoV-2 can mutate and compromise the effectiveness of vaccines and treatments.”

Research highlights:

• A strong preventive and therapeutic effect on SARS-CoV-2 was observed in rhesus monkeys. This is because it is a widely used model for assessing the efficacy of SARS-CoV-2 treatments and vaccines and is a strict reflection of human infections and illnesses. A single dose of ABP 300 blocked SARS-CoV-2 infection in prophylactic treatment and eliminated SARS-CoV-2 in 3 days in the therapeutic setting.
• ABP-300 has been shown to be protective by reducing lung lesions caused by SARS-CoV-2 in monkeys, whether or not the antibody was injected before or after the viral attack.
• ABP 300 showed high RBD binding ability and strong ability to break RBD / ACE2 binding, effectively neutralizing both SARS-CoV-2 pseudovirus and real live virus.
• ABP-300, known as MW05, an additional antibody from the Abpro program, and MW07, an additional antibody, show strong binding capacity to eight high-frequency mutant RBD proteins and viral interactions with host cells. Blocked. These results suggest that both monoclonal antibodies may neutralize a wide range of SARS-CoV-2 strains.

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