Health
Scientists redesign bacteria to attack pathogens and leave healthy cells intact — RT World News
Scientists have successfully redesigned bacteria that normally attack human cells and attack pathogens, increasing the arsenal that humans can deploy to protect themselves from disease.
Many pathogenic (cause of disease) bacteria utilize certain types of proteins and use them as battering rams to break through the host’s cell membranes and kill them.
The type of protein targeted is called cholesterol-dependent cytolysin (CDC). Cholesterol is a fat molecule that makes up the human cell wall, and the CDC is particularly good at puncturing these membranes.
By using a technique called cryo-electron microscopy, researchers at Imperial College London and University College London have changed the shape of the CDC and rearranged the proteins side-by-side to increase the speed of the CDC during punching. I was able to accurately observe how it was dropped and the cell wall was destroyed. Slide the sides and spiral structure into place.
Scientists then discovered that by manipulating the properties of this helix, the target bacteria could be persuaded to remove their dependence on cholesterol and instead attack other pathogens.
Boffin share Blueprint for diversion of these “Bacterial nanomachine” In a study published in Nature this week.
“We have discovered how this process can be designed and redirected to attack new types of cells. It is a weapon for changing the table of pathogens and fighting them. May increase. “ Dr. Doryen Boubeck of the Department of Life Sciences at Imperial College says.
In addition, the technology can be applied not only to the myriad pathogens that attack plants, but also to some bacteria that are harmful to humans.
The protein in question is also found within our own immune system. Perhaps careful adjustment opens the door to a whole new approach to strengthening our own defenses.
“What’s really exciting is that this special helix used by the CDC is found not only in pathogens, but also in many other types of proteins as part of our own immune system.” Dr. Nita Shah, the lead author of the study, explained.
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